Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jan;14(1):13-24.
doi: 10.1038/nrm3488. Epub 2012 Dec 5.

The nuclear lamins: flexibility in function

Brian Burke  1 , Colin L Stewart
Affiliations
Review

The nuclear lamins: flexibility in function

Brian Burke et al. Nat Rev Mol Cell Biol. 2013 Jan.

Abstract

The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear envelope proteins. The major components of the lamina are the A-type and B-type lamins, which are members of the intermediate filament protein family. Whereas the expression of A-type lamins is developmentally regulated, B-type lamins, as a class, are found in all cells. The association of B-type lamins with many aspects of nuclear function has led to the view that these are essential proteins, and there is growing evidence suggesting that they regulate cellular senescence. However, B-type lamins are dispensable in certain cell types in vivo, and neither A-type nor B-type lamins may be required in early embryos or embryonic stem cells. The picture that is beginning to emerge is of a complex network of interactions at the nuclear periphery that may be defined by cell- and tissue-specific functions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Science. 2002 Oct 11;298(5592):406-9 - PubMed
    1. Curr Opin Genet Dev. 2009 Apr;19(2):180-6 - PubMed
    1. J Cell Sci Suppl. 1984;1:137-60 - PubMed
    1. Biophys J. 2008 Dec;95(11):5462-75 - PubMed
    1. Nature. 1986 Feb 6-12;319(6053):463-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources