Sodium-sulfate/carboxylate cotransporters (SLC13)
- PMID: 23177988
- DOI: 10.1016/B978-0-12-394316-3.00007-7
Sodium-sulfate/carboxylate cotransporters (SLC13)
Abstract
The SLC13 gene family is comprised of five sequence related proteins that are found in animals, plants, yeast and bacteria. Proteins encoded by the SLC13 genes are divided into the following two groups of transporters with distinct anion specificities: the Na(+)-sulfate (NaS) cotransporters and the Na(+)-carboxylate (NaC) cotransporters. Members of this gene family (in ascending order) are: SLC13A1 (NaS1), SLC13A2 (NaC1), SLC13A3 (NaC3), SLC13A4 (NaS2) and SLC13A5 (NaC2). SLC13 proteins encode plasma membrane polypeptides with 8-13 putative transmembrane domains, and are expressed in a variety of tissues. They are all Na(+)-coupled symporters with strong cation preference for Na(+), and insensitive to the stilbene 4, 4'-diisothiocyanatostilbene-2, 2'-disulphonic acid (DIDS). Their Na(+):anion coupling ratio is 3:1, indicative of electrogenic properties. They have a substrate preference for divalent anions, which include tetra-oxyanions for the NaS cotransporters or Krebs cycle intermediates (including mono-, di- and tricarboxylates) for the NaC cotransporters. This review will describe the molecular and cellular mechanisms underlying the biochemical, physiological and structural properties of the SLC13 gene family.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
-
The SLC13 gene family of sodium sulphate/carboxylate cotransporters.Pflugers Arch. 2004 Feb;447(5):594-602. doi: 10.1007/s00424-003-1128-6. Epub 2003 Aug 12. Pflugers Arch. 2004. PMID: 12915942 Review.
-
SLC13 family of Na⁺-coupled di- and tri-carboxylate/sulfate transporters.Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. doi: 10.1016/j.mam.2012.12.001. Mol Aspects Med. 2013. PMID: 23506872 Review.
-
Functional characteristics of NaS2, a placenta-specific Na+-coupled transporter for sulfate and oxyanions of the micronutrients selenium and chromium.Placenta. 2006 Jun-Jul;27(6-7):550-9. doi: 10.1016/j.placenta.2005.05.004. Epub 2005 Aug 29. Placenta. 2006. PMID: 16129486
-
Functional and structural characterization of the zebrafish Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1).Physiol Genomics. 2008 Aug 15;34(3):256-64. doi: 10.1152/physiolgenomics.90234.2008. Epub 2008 Jun 10. Physiol Genomics. 2008. PMID: 18544660
-
Sodium-coupled transporters for Krebs cycle intermediates.Annu Rev Physiol. 1999;61:663-82. doi: 10.1146/annurev.physiol.61.1.663. Annu Rev Physiol. 1999. PMID: 10099705 Review.
Cited by
-
Why Nature Chose Potassium.J Mol Evol. 2019 Dec;87(9-10):271-288. doi: 10.1007/s00239-019-09915-2. Epub 2019 Oct 28. J Mol Evol. 2019. PMID: 31659374 Review.
-
Energetic evolution of cellular Transportomes.BMC Genomics. 2018 May 30;19(1):418. doi: 10.1186/s12864-018-4816-5. BMC Genomics. 2018. PMID: 29848286 Free PMC article.
-
The SLC transporter in nutrient and metabolic sensing, regulation, and drug development.J Mol Cell Biol. 2019 Jan 1;11(1):1-13. doi: 10.1093/jmcb/mjy052. J Mol Cell Biol. 2019. PMID: 30239845 Free PMC article.
-
Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family.Pflugers Arch. 2014 Jan;466(1):119-30. doi: 10.1007/s00424-013-1369-y. Epub 2013 Oct 10. Pflugers Arch. 2014. PMID: 24114175 Review.
-
Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.Sci Adv. 2024 Mar 29;10(13):eadl3685. doi: 10.1126/sciadv.adl3685. Epub 2024 Mar 29. Sci Adv. 2024. PMID: 38552027 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
