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. 2013 Aug;94(8):1580-3.
doi: 10.1016/j.apmr.2012.11.006. Epub 2012 Nov 12.

Correlation between voluntary cough and laryngeal cough reflex flows in patients with traumatic brain injury

Sang Chul Lee  1 , Seong-Woong Kang, Min Tae Kim, Yong Kyun Kim, Won Hyuk Chang, Sang Hee Im
Affiliations

Correlation between voluntary cough and laryngeal cough reflex flows in patients with traumatic brain injury

Sang Chul Lee et al. Arch Phys Med Rehabil. 2013 Aug.

Abstract

Objective: To correlate voluntary cough and laryngeal cough reflex (LCR) flows in patients with traumatic brain injury (TBI).

Design: Cross-sectional study.

Setting: University rehabilitation hospital.

Participants: Patients with TBI (n=25) and healthy controls (n=48).

Interventions: Not applicable.

Main outcome measures: Peak cough flows (PCFs) and LCR flows were measured using a peak flow meter at the oral-nasal interface. The largest value of 3 attempts was recorded for PCF and LCR, respectively. LCR was elicited by 20% solution of pharmaceutic-grade citric acid dissolved in sterile .15M NaCl solution that was inhaled from a nebulizer.

Results: PCF was 447.4 ± 99.0 L/min in the control group and 211.7 ± 58.2 L/min in the patient group. LCR was 209.2 ± 63.8L/min in the control group and 170.0 ± 59.7 L/min in the patient group. Both PCF (P=.000) and LCR (P=.013) were significantly reduced in patients with TBI compared to that of the control group. LCR was strongly related to the PCF in both control (R=.645; P=.000) and patient (R=.711; P=.000) groups.

Conclusions: As LCR can be measured as a numerical value and significantly correlates with PCF, LCR can be used to estimate cough ability of patients with TBI who cannot cooperate with PCF measurement.

Keywords: Aspiration; Brain injuries; Cough; LCR; MMSE; Mini-Mental State Examination; PCF; Rehabilitation; TBI; laryngeal cough reflex; peak cough flow; traumatic brain injury.

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