Impact of susceptibility profiles of Gram-negative bacteria before and after the introduction of ertapenem at a medical center in northern Taiwan from 2004 to 2010
- PMID: 23116904
- DOI: 10.1016/j.diagmicrobio.2012.09.018
Impact of susceptibility profiles of Gram-negative bacteria before and after the introduction of ertapenem at a medical center in northern Taiwan from 2004 to 2010
Abstract
This retrospective observational study evaluated the impact of antimicrobial consumption on antimicrobial susceptibility among aerobic Gram-negative bacteria after introducing ertapenem to the formulary of a teaching hospital (1130 beds) in northern Taiwan. Data on consumption of various antimicrobial agents, expressed as defined daily dose/1000 patient-days (DDD/1000 PD), were collected retrospectively from hospital pharmacy records 2 years before and 5 years after the introduction of ertapenem (October 2005). During the study period, the consumption of ampicillin and aminoglycosides decreased significantly. In contrast, the consumption of cefoxitin, ceftazidime, cefpirome, piperacillin-tazobactam, carbapenems (ertapenem, imipenem, and meropenem), and fluoroquinolones (ciprofloxacin, levofloxacin, and moxifloxacin) increased significantly over time. There was a significant increase in the rate of susceptibility of Escherichia coli to ampicillin, cefotaxime, ceftazidime, piperacillin-tazobactam, cefpirome, amikacin, and levofloxacin; an increase in the rate of susceptibility of Klebsiella pneumoniae to ceftazidime, cefepime, cefpirome, piperacillin-tazobactam, meropenem, levofloxacin, and amikacin; a significant decrease in the rate of susceptibility of Pseudomonas aeruginosa to meropenem; and a significant decrease in the rate of susceptibility of Acinetobacter baumannii to ceftazidime, carbapenems, ciprofloxacin, and levofloxacin. The rate of antibiotic susceptibility to ertapenem of extended spectrum β-lactamase producers, including E. coli and K. pneumoniae, remained stable. Usage of ertapenem was found to be negatively and significantly associated with the susceptibility rates of P. aeruginosa to meropenem and gentamicin. Significantly negative correlations were noted between the use of ertapenem and the rates of susceptibility of A. baumannii to ceftazidime, piperacillin-tazobactam, carbapenems (imipenem and meropenem), ciprofloxacin, and levofloxacin.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
-
Relationships between antimicrobial use and antimicrobial resistance in Gram-negative bacteria causing nosocomial infections from 1991-2003 at a university hospital in Taiwan.Int J Antimicrob Agents. 2005 Dec;26(6):463-72. doi: 10.1016/j.ijantimicag.2005.08.016. Epub 2005 Nov 8. Int J Antimicrob Agents. 2005. PMID: 16280243 Free PMC article.
-
Comparative antimicrobial susceptibility of aerobic and facultative bacteria from community-acquired bacteremia to ertapenem in Taiwan.BMC Infect Dis. 2007 Jul 17;7:79. doi: 10.1186/1471-2334-7-79. BMC Infect Dis. 2007. PMID: 17640342 Free PMC article.
-
[Antimicrobial resistance of Gram-negative bacilli isolated from 13 teaching hospitals across China].Zhonghua Yi Xue Za Zhi. 2013 May 14;93(18):1388-96. Zhonghua Yi Xue Za Zhi. 2013. PMID: 24025503 Chinese.
-
An update on the management of urinary tract infections in the era of antimicrobial resistance.Postgrad Med. 2017 Mar;129(2):242-258. doi: 10.1080/00325481.2017.1246055. Epub 2016 Oct 21. Postgrad Med. 2017. PMID: 27712137 Review.
-
Carbapenem stewardship: does ertapenem affect Pseudomonas susceptibility to other carbapenems? A review of the evidence.Int J Antimicrob Agents. 2012 Jan;39(1):11-5. doi: 10.1016/j.ijantimicag.2011.08.018. Epub 2011 Nov 1. Int J Antimicrob Agents. 2012. PMID: 22047702 Review.
Cited by
-
Correlation between Carbapenem Consumption and Carbapenems Susceptibility Profiles of Acinetobacter baumannii and Pseudomonas aeruginosa in an Academic Medical Center in Thailand.Antibiotics (Basel). 2022 Jan 23;11(2):143. doi: 10.3390/antibiotics11020143. Antibiotics (Basel). 2022. PMID: 35203746 Free PMC article.
-
Carbapenem stewardship with ertapenem and antimicrobial resistance-a scoping review.Rev Soc Bras Med Trop. 2020 Nov 6;53:e20200413. doi: 10.1590/0037-8682-0413-2020. eCollection 2020. Rev Soc Bras Med Trop. 2020. PMID: 33174959 Free PMC article. Review.
-
Effects of Group 1 versus Group 2 carbapenems on the susceptibility of Acinetobacter baumannii to carbapenems: a before and after intervention study of carbapenem-use stewardship.PLoS One. 2014 Jun 9;9(6):e99101. doi: 10.1371/journal.pone.0099101. eCollection 2014. PLoS One. 2014. PMID: 24911244 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials