New insights into an old disease: advanced imaging in the diagnosis and management of gout
- PMID: 23112219
- DOI: 10.1136/postgradmedj-2012-131000
New insights into an old disease: advanced imaging in the diagnosis and management of gout
Abstract
Advanced imaging modalities including MRI, ultrasound (US), CT and dual energy CT have important applications in gout. While conventional radiography (X-ray) remains the most widely used form of imaging in the clinical setting and is helpful in revealing erosions in chronic gout, these new imaging tools can reveal joint damage and tophi at a much earlier stage. As all are multiplanar techniques, they can define the position and dimensions of tophi, with startling clarity, as well as the size and extent of bone erosions. US and MRI also reveal the severity of inflammation within and adjacent to the joint and can capture information about the composite, vascular nature of many tophaceous deposits. These features can be used as imaging outcome measures, to monitor responses to anti-inflammatory and urate lowering therapies. The new possibility that gout could be diagnosed using imaging, without aspirating the joint, is on the horizon. This review discusses the clinical and research applications of advanced imaging in gout with particular focus on diagnosis and monitoring of joint inflammation and damage.
Similar articles
-
Imaging in gout--what can we learn from MRI, CT, DECT and US?Arthritis Res Ther. 2011;13(6):246. doi: 10.1186/ar3489. Epub 2011 Nov 4. Arthritis Res Ther. 2011. PMID: 22085684 Free PMC article. Review.
-
Imaging tools to measure treatment response in gout.Rheumatology (Oxford). 2018 Jan 1;57(suppl_1):i27-i34. doi: 10.1093/rheumatology/kex445. Rheumatology (Oxford). 2018. PMID: 29272513 Review.
-
Gout: can we create an evidence-based systematic approach to diagnosis and management?Best Pract Res Clin Rheumatol. 2006 Aug;20(4):673-84. doi: 10.1016/j.berh.2006.05.006. Best Pract Res Clin Rheumatol. 2006. PMID: 16979531 Review.
-
Mechanisms of joint damage in gout: evidence from cellular and imaging studies.Nat Rev Rheumatol. 2012 Jan 10;8(3):173-81. doi: 10.1038/nrrheum.2011.207. Nat Rev Rheumatol. 2012. PMID: 22231231 Review.
-
[Multimodality imaging of chronic tophaceous gout].Reumatismo. 2010 Oct-Dec;62(4):286-91. doi: 10.4081/reumatismo.2010.286. Reumatismo. 2010. PMID: 21253623 Italian.
Cited by
-
Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential.J Inflamm Res. 2024 Mar 19;17:1735-1763. doi: 10.2147/JIR.S460333. eCollection 2024. J Inflamm Res. 2024. PMID: 38523684 Free PMC article. Review.
-
Reliability of knee joint sonography in the evaluation of gouty arthritis.J Ultrason. 2021 Nov 29;21(87):e300-e305. doi: 10.15557/JoU.2021.0051. Epub 2021 Dec 15. J Ultrason. 2021. PMID: 34970441 Free PMC article.
-
Metal artifact reduction and tumor detection using photon-counting multi-energy computed tomography.PLoS One. 2021 Mar 5;16(3):e0247355. doi: 10.1371/journal.pone.0247355. eCollection 2021. PLoS One. 2021. PMID: 33667250 Free PMC article.
-
Ultrasonography and dual-energy computed tomography: impact for the detection of gouty deposits.Ultrasonography. 2021 Apr;40(2):197-206. doi: 10.14366/usg.20063. Epub 2020 Oct 2. Ultrasonography. 2021. PMID: 33307617 Free PMC article.
-
Relationship between urate within tophus and bone erosion according to the anatomic location of urate deposition in gout: A quantitative analysis using dual-energy CT volume measurements.Medicine (Baltimore). 2019 Dec;98(51):e18431. doi: 10.1097/MD.0000000000018431. Medicine (Baltimore). 2019. PMID: 31861011 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
