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. 2012 Dec;18(6):532-7.
doi: 10.1007/s13365-012-0131-0. Epub 2012 Oct 18.

Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

Laura Polledo  1 , Jorge González, Julio Benavides, Beatriz Martínez-Fernández, Ma Carmen Ferreras, Juan F García Marín
Affiliations

Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

Laura Polledo et al. J Neurovirol. 2012 Dec.

Abstract

We examined the distribution in the perivascular spaces of Visna/maedi antigen, T cells (CD3+, CD4+ and CD8+), B cells and macrophages by immunohistochemistry in 22 natural cases of Visna/maedi encephalitis. Sheep showed lymphocytic or histiocytic lesions. In mild lymphocytic lesions, the viral antigen was detected in perivascular cuffs where CD8+ T cells predominated, but in severe lymphocytic lesions, sparse antigen was identified, and CD8+/CD4+ T cells appeared in a similar proportion in multilayer perivascular sleeves. In histiocytic lesions, vessels were surrounded by macrophages with abundant viral antigen, with CD8+/CD4+ T cells and B cells in the periphery. These results could reflect different stages of virus neuroinvasion and clarify the neuropathogenesis of Visna/maedi encephalitis.

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References

    1. J Immunol. 2001 Nov 1;167(9):5429-38 - PubMed
    1. J Neurovirol. 2004 Oct;10(5):315-25 - PubMed
    1. Vet Rec. 2006 Feb 18;158(7):230-5 - PubMed
    1. Immunol Res. 2011 Apr;49(1-3):135-46 - PubMed
    1. J Exp Med. 2001 Apr 16;193(8):905-15 - PubMed

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