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. 2012 Sep 24:3:353.
doi: 10.3389/fphys.2012.00353. eCollection 2012.

Macrophages in collateral arteriogenesis

Erik Fung  1 , Armin Helisch
Affiliations

Macrophages in collateral arteriogenesis

Erik Fung et al. Front Physiol. .

Abstract

Arteriosclerotic vascular disease is the most common cause of death and a major cause of disability in the developed world. Adverse outcomes of arteriosclerotic vascular disease are related to consequences of tissue ischemia and necrosis affecting the heart, brain, limbs, and other organs. Collateral artery growth or arteriogenesis occurs naturally and can help restore perfusion to ischemic tissues. Understanding the mechanisms of collateral artery growth may provide therapeutic options for patients with ischemic vascular disease. In this review, we examine the evidence for a role of monocytes and macrophages in collateral arteriogenesis.

Keywords: angiogenesis; arteriogenesis; collateral artery; growth; macrophages; monocytes; remodeling; vascular.

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Figures

Figure 1
Figure 1
Coronary angiography of a 69-year-old male with chest pain (Canadian Cardiovascular Society Class IV) revealed occlusive coronary artery disease in the mid segment of the left anterior descending artery (*) bypassed naturally with collateral arterioles (↓) from the right coronary artery. The figure is taken from the cineangiogram in Supplementary Material during contrast injection into the right coronary artery. C, angiographic catheter; RCA, right coronary artery. Supplementary Material (Movie 1.MPG).
Figure 2
Figure 2
Digital subtraction angiography performed during abdominal aortography and peripheral arteriography on a 68-year-old female with lifestyle-limiting intermittent claudication showing an occluded right common iliac artery (*), and development of collateral vessels (↓) involving the middle sacral artery, right lumbar arteries, and other branches, to supply the right lower extremity. Compared with arteries on the left side, note the extensive outward remodeling on the right characterized by increased vessel diameter, tortuosity, and density as a consequence of the right-sided occlusion. Ao, abdominal aorta; LCIA, left common iliac artery; LLA, left lumbar artery; MSA, middle sacral artery; RLA, right lumbar artery.
Figure 3
Figure 3
(A) Donor-derived cells (labeled with anti-GFP antibody, green) accumulating around collateral artery, after bone marrow transplantation from GFP expressing donor mice and femoral artery ligation. (B) Several of the bone marrow-derived cells express F4/80 (red), a marker for macrophages. With permission from (Ziegelhoeffer et al., 2004).
See this image and copyright information in PMC

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