Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jan;25(1):229-35.
doi: 10.1016/j.cellsig.2012.09.026. Epub 2012 Sep 27.

Functional roles for myosin 1c in cellular signaling pathways

Lisa M Bond  1 , Hemma Brandstaetter, John Kendrick-Jones, Folma Buss
Affiliations
Review

Functional roles for myosin 1c in cellular signaling pathways

Lisa M Bond et al. Cell Signal. 2013 Jan.

Abstract

Cellular signaling pathways underlie the transfer of information throughout the cell and to adjoining cells and so govern most critical cellular functions. Increasing evidence points to the molecular motor myosin 1c as a prominent player in many signaling cascades, from the integrin-dependent signaling involved in cell migration to the signaling events underlying insulin resistance. Myosin 1c functions on these pathways both via an important role in regulating lipid raft recycling and also via direct involvement in signaling cascades. This review provides an overview of the functional involvement of myosin 1c in cellular signaling and discusses the possible potential for myosin 1c as a target for drug-based treatments for human diseases.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Myosin 1c in cellular signaling pathways. This figure provides an overview of the cellular signaling pathways involving myosin 1c function. In particular, myosin 1c has been shown to play a role in (1) the integrin-mediated signaling pathways underlying cell migration, (2) the signaling events facilitating pathogen uptake by macropinocytosis, (3) the Neph1 translocation and signaling mediating podocyte foot formation, (4) the tumor necrosis factor-alpha (TNF-α)-induced insulin resistance pathways, (5) insulin-stimulated GLUT4 transport to the plasma membrane, and (6) mechanical signal transduction in the hair cells of the inner ear. The molecular role of myosin 1c in each pathway is outlined and additional key signaling players are displayed for reference. This presentation of the diverse assembly of signaling pathways involving myosin 1c function highlights the importance of this motor in cellular signaling. Abbreviations: FAK (focal adhesion kinase), PAK1 (p21-activated kinase 1), CtBP1 (C-terminal binding protein 1), Nck (non-catalytic region of tyrosine kinase adaptor protein 1), Grb2 (growth factor receptor-bound protein 2), IKK (IκB kinase), IRS-1 (insulin receptor substrate 1), CaMKII (Ca2 +/calmodulin-dependent protein kinase II), Ca2 + (Calcium), ATP (adenosine triphosphate), and PIP2 (phosphatidylinositol 4,5-bisphosphate).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hancock J. 3rd ed. Oxford University Press; USA: 2010. Cell Signalling.
    1. Keegan A.D., Paul W.E. Immunology Today. 1992;13:63. - PubMed
    1. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Endocrine Reviews. 2001;22:153. - PubMed
    1. Logan C.Y., Nusse R. Annual Review of Cell and Developmental Biology. 2004;20:781. - PubMed
    1. Taha C., Klip A. The Journal of Membrane Biology. 1999;169:1. - PubMed

Publication types

LinkOut - more resources