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Review
. 2013 Feb;6(1):228-37.
doi: 10.1161/CIRCEP.111.962050. Epub 2012 Sep 28.

Dilated cardiomyopathy

Neal K Lakdawala  1 , Jeffery R Winterfield, Birgit H Funke
Affiliations
Review

Dilated cardiomyopathy

Neal K Lakdawala et al. Circ Arrhythm Electrophysiol. 2013 Feb.
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: None

Figures

Figure 1
Figure 1
Inheritance and Expression Patterns in Familial DCM. Disease transmission from father to son supports autosomal dominant inheritance (arrow). Incomplete penetrance is demonstrated by individual A, who has no evidence of DCM but is an obligate carrier of a disease variant by virtue of having an affected father and son. Variable clinical expression is evident with clinical manifestations differing amongst affected individuals within the kindred, which may obscure recognition of shared genetic disease. In this family, the presence of arrhythmias, conduction disease and DCM are consistent with disease caused by a mutation in LMNA, which was subsequently identified in individual B. Black symbols = clinically affected individuals; white symbols = clinically unaffected individuals; circle=female; square=male; slash=deceased. + = LMNA mutation positive; − = LMNA mutation negative; AF = atrial fibrillation; AVB = atrioventricular block; LVEF = left ventricular ejection fraction; SCD = sudden cardiac death.
Figure 2
Figure 2
Non-Coronary Pattern of Delayed Gadolinium Enhancement imaged with Cardiac MRI in Familial DCM. Short axis Cardiac MRI (CMR) images reveal circumferential subepicardial delayed enhancement (DE) of gadolinium (arrows) in a young patient with familial DCM and palmoplantar keratoderma caused by a DSP mutation. The pattern of delayed enhancement of gadolinium is not specific for genetic heart disease, but is distinct from ischemic cardiomyopathy. LV = left ventricle; RV = right ventricle. Images courtesy of Ravi Shah, MD and Raymond Kwong, MD, Brigham and Women’s Hospital, Boston, MA.
See this image and copyright information in PMC

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