Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012:90:163-86.
doi: 10.1016/B978-0-12-398313-8.00007-5.

Glucocorticoid effects on adiponectin expression

Siddharth Sukumaran  1 , Debra C Dubois, William J Jusko, Richard R Almon
Affiliations
Review

Glucocorticoid effects on adiponectin expression

Siddharth Sukumaran et al. Vitam Horm. 2012.

Abstract

Maintenance of energy metabolism and glucose homeostasis is achieved by the regulatory effects of many hormones and their interactions. Glucocorticoids produced from adrenal cortex and adiponectin produced by adipose tissue play important roles in the production, distribution, storage, and utilization of energy substrates. Glucocorticoids are involved in the activation of a number of catabolic processes by affecting the expression of a plethora of genes, while adiponectin acts primarily as an insulin sensitizer. Both are regulated by a number of physiological and pharmacological factors. Although the effects of glucocorticoids on adiponectin expression have been extensively studied in different in vitro, animal and clinical study settings, no consensus has been reached. This report reviews the primary literature concerning the effects of glucocorticoids on adiponectin expression and identifies potential reasons for the contradictory results between different studies. In addition, methods to gain better insights pertaining to the regulation of adiponectin expression are discussed.

PubMed Disclaimer

Figures

Figure 7.1
Figure 7.1
Regulation of glucocorticoids production by hypothalamic–pituitary–adrenal axis represents inhibition in the production.
Figure 7.2
Figure 7.2
Molecular mechanism for the regulation of gene expression by glucocorticoids.
Figure 7.3
Figure 7.3
Factors regulating adiponectin expression.
Figure 7.4
Figure 7.4
Effects of methylprednisolone dosing on adiponectin mRNA expression in white adipose tissue (left) and plasma adiponectin concentrations (right) in Wistar rats. Solid squares represent the measured data and solid curve represents the prediction from the mathematical model (Sukumaran et al., 2011).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Almon RR, DuBois DC, Jusko WJ. A microarray analysis of the temporal response of liver to methylprednisolone: A comparative analysis of two dosing regimens. Endocrinology. 2007;148:2209–2225. - PMC - PubMed
    1. Almon RR, DuBois DC, Pearson KE, Stephan DA, Jusko WJ. Gene arrays and temporal patterns of drug response: Corticosteroid effects on rat liver. Functional & Integrative Genomics. 2003;3:171–179. - PMC - PubMed
    1. Almon RR, DuBois DC, Piel WH, Jusko WJ. The genomic response of skeletal muscle to methylprednisolone using microarrays: Tailoring data mining to the structure of the pharmacogenomic time series. Pharmacogenomics. 2004;5:525–552. - PMC - PubMed
    1. Almon RR, DuBois DC, Yao Z, Hoffman EP, Ghimbovschi S, Jusko WJ. Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: Comparative analysis of two dosing regimens. Physiological Genomics. 2007;30:282–299. - PMC - PubMed
    1. Almon RR, Lai W, DuBois DC, Jusko WJ. Corticosteroid-regulated genes in rat kidney: Mining time series array data. American Journal of Physiology. Endocrinology and Metabolism. 2005;289:E870–E882. - PMC - PubMed

Publication types