Review
doi: 10.3109/10409238.2012.714350.
Epub 2012 Sep 18.
A-to-I editing of protein coding and noncoding RNAs
Affiliations
- PMID: 22988838
- DOI: 10.3109/10409238.2012.714350
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Review
A-to-I editing of protein coding and noncoding RNAs
Crit Rev Biochem Mol Biol.
2012 Nov-Dec.
Abstract
Adenosine deaminase acting on RNA (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) substrates. Inosine pairs preferentially with cytidine, as opposed to uridine; therefore, ADAR editing alters the sequence and base pairing properties of both protein-coding and non-coding RNA. Editing can directly alter the sequence of protein-coding transcripts and modify splicing, or affect a variety of non-coding targets, including microRNA, small interfering RNA, viral transcripts, and repeat elements such as Alu and LINE. Such editing has a wide range of physiological effects, including modification of targets in the brain and in disease states.
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