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Review
. 2013 Jan;126(1):3-15.
doi: 10.1007/s10265-012-0518-2. Epub 2012 Aug 26.

How do 'housekeeping' genes control organogenesis?--Unexpected new findings on the role of housekeeping genes in cell and organ differentiation

Hirokazu Tsukaya  1 , Mary E Byrne, Gorou Horiguchi, Munetaka Sugiyama, Mieke Van Lijsebettens, Michael Lenhard
Affiliations
Review

How do 'housekeeping' genes control organogenesis?--Unexpected new findings on the role of housekeeping genes in cell and organ differentiation

Hirokazu Tsukaya et al. J Plant Res. 2013 Jan.

Abstract

In recent years, an increasing number of mutations in what would appear to be 'housekeeping genes' have been identified as having unexpectedly specific defects in multicellular organogenesis. This is also the case for organogenesis in seed plants. Although it is not surprising that loss-of-function mutations in 'housekeeping' genes result in lethality or growth retardation, it is surprising when (1) the mutant phenotype results from the loss of function of a 'housekeeping' gene and (2) the mutant phenotype is specific. In this review, by defining housekeeping genes as those encoding proteins that work in basic metabolic and cellular functions, we discuss unexpected links between housekeeping genes and specific developmental processes. In a surprising number of cases housekeeping genes coding for enzymes or proteins with functions in basic cellular processes such as transcription, post-transcriptional modification, and translation affect plant development.

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References

    1. Plant Signal Behav. 2011 May;6(5):712-4 - PubMed
    1. Curr Biol. 2011 Jun 21;21(12):999-1008 - PubMed
    1. Development. 2001 Nov;128(21):4289-99 - PubMed
    1. Trends Plant Sci. 2009 Sep;14(9):512-9 - PubMed
    1. J Integr Plant Biol. 2008 Jul;50(7):897-905 - PubMed

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