Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Dec;10(4):258-69.
doi: 10.1007/s11914-012-0115-2.

Heart failure as a risk factor for osteoporosis and fractures

Aloice O Aluoch  1 , Ryan Jessee, Hani Habal, Melinda Garcia-Rosell, Rehan Shah, Guy Reed, Laura Carbone
Affiliations
Review

Heart failure as a risk factor for osteoporosis and fractures

Aloice O Aluoch et al. Curr Osteoporos Rep. 2012 Dec.

Abstract

Although heart failure (HF) and osteoporosis are common diseases, particularly in elderly populations, patients with HF have an increased risk for osteoporosis. The relationship of HF with osteoporosis is modified by gender and the severity of HF. In addition, shared risk factors, medication use, and common pathogenic mechanisms affect both HF and osteoporosis. Shared risk factors for these 2 conditions include advanced age, hypovitaminosis D, renal disease, and diabetes mellitus. Medications used to treat HF, including spironolactone, thiazide diuretics, nitric oxide donors, and aspirin, may protect against osteoporosis. In contrast, loop diuretics may make osteoporosis worse. HF and osteoporosis appear to share common pathogenic mechanisms, including activation of the renin-angiotensin-aldosterone system, increased parathyroid hormone levels, and/or oxidative/nitrosative stress. HF is a major risk factor for mortality following fractures. Thus, in HF patients, it is important to carefully assess osteoporosis and take measures to reduce the risk of osteoporotic fractures.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Arch Intern Med. 2001 Apr 9;161(7):996-1002 - PubMed
    1. Ann Intern Med. 2012 Jan 3;156(1 Pt 1):27-36 - PubMed
    1. J Am Coll Cardiol. 2001 Nov 1;38(5):1581-3 - PubMed
    1. J Clin Hypertens (Greenwich). 2012 Feb;14(2):112-20 - PubMed
    1. Menopause. 2010 Jan-Feb;17(1):57-63 - PubMed

MeSH terms

LinkOut - more resources