Inhibitors targeting on cell wall biosynthesis pathway of MRSA
- PMID: 22898792
- DOI: 10.1039/c2mb25188d
Inhibitors targeting on cell wall biosynthesis pathway of MRSA
Abstract
Methicillin resistant Staphylococcus aureus (MRSA), widely known as a type of new superbug, has aroused world-wide concern. Cell wall biosynthesis pathway is an old but good target for the development of antibacterial agents. Peptidoglycan and wall teichoic acids (WTAs) biosynthesis are two main processes of the cell wall biosynthesis pathway (CWBP). Other than penicillin-binding proteins (PBPs), some key factors (Mur enzymes, lipid I or II precursor, etc.) in CWBP are becoming attractive molecule targets for the discovery of anti-MRSA compounds. A number of new compounds, with higher affinity for PBPs or with inhibitory activity on such molecule targets in CWBP of MRSA, have been in the pipeline recently. This review concludes recent research achievements and provides a complete picture of CWBP of MRSA, including the peptidoglycan and wall teichoic acids synthesis pathway. The potential inhibitors targeting on CWBP are subsequently presented to improve development of novel therapeutic strategies for MRSA.
Similar articles
-
New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus.J Antibiot (Tokyo). 2013 May;66(5):303-4. doi: 10.1038/ja.2012.122. Epub 2013 Jan 23. J Antibiot (Tokyo). 2013. PMID: 23340661 No abstract available.
-
The Role of β-Glycosylated Wall Teichoic Acids in the Reduction of Vancomycin Susceptibility in Vancomycin-Intermediate Staphylococcus aureus.Microbiol Spectr. 2021 Oct 31;9(2):e0052821. doi: 10.1128/Spectrum.00528-21. Epub 2021 Oct 20. Microbiol Spectr. 2021. PMID: 34668723 Free PMC article.
-
TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.Sci Transl Med. 2016 Mar 9;8(329):329ra32. doi: 10.1126/scitranslmed.aad7364. Sci Transl Med. 2016. PMID: 26962156
-
An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway.Int J Med Microbiol. 2010 Feb;300(2-3):161-9. doi: 10.1016/j.ijmm.2009.10.005. Epub 2009 Dec 14. Int J Med Microbiol. 2010. PMID: 20005776 Review.
-
Taking aim at wall teichoic acid synthesis: new biology and new leads for antibiotics.J Antibiot (Tokyo). 2014 Jan;67(1):43-51. doi: 10.1038/ja.2013.100. Epub 2013 Oct 30. J Antibiot (Tokyo). 2014. PMID: 24169797 Review.
Cited by
-
A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA).Molecules. 2023 Oct 10;28(20):7008. doi: 10.3390/molecules28207008. Molecules. 2023. PMID: 37894491 Free PMC article. Review.
-
Molecular docking and inhibition studies on the interactions of Bacopa monnieri's potent phytochemicals against pathogenic Staphylococcus aureus.Daru. 2015 Apr 17;23(1):26. doi: 10.1186/s40199-015-0106-9. Daru. 2015. PMID: 25884228 Free PMC article.
-
Identification of potential targets in Staphylococcus aureus N315 using computer aided protein data analysis.Bioinformation. 2013;9(4):187-92. doi: 10.6026/97320630009187. Epub 2013 Feb 21. Bioinformation. 2013. PMID: 23519164 Free PMC article.
-
Antibacterial drug leads targeting isoprenoid biosynthesis.Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. Epub 2012 Dec 17. Proc Natl Acad Sci U S A. 2013. PMID: 23248302 Free PMC article.
-
Computational Target-Based Screening of Anti-MRSA Natural Products Reveals Potential Multitarget Mechanisms of Action through Peptidoglycan Synthesis Proteins.ACS Omega. 2022 Oct 14;7(42):37896-37906. doi: 10.1021/acsomega.2c05061. eCollection 2022 Oct 25. ACS Omega. 2022. PMID: 36312373 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
