Specific CD8⁺ T cells recognize human herpesvirus 6B
- PMID: 22886850
- DOI: 10.1002/eji.201242439
Specific CD8⁺ T cells recognize human herpesvirus 6B
Abstract
The importance of human herpesvirus 6 (HHV-6) species as human pathogens is increasingly appreciated. However, we do not understand how infection is controlled in healthy virus carriers, and why control fails in patients with disease. Other persistent viruses are under continuous surveillance by antigen-specific T cells, and specific T-cell repertoires have been well characterized for some of them. In contrast, knowledge on HHV-6-specific T-cell responses is limited, and missing for CD8(+) T cells. Here we identify CD8(+) T-cell responses to HHV-6B, the most widespread HHV-6 species, in healthy virus carriers. HHV-6B-specific CD8(+) T-cell lines and clones recognized HLA-A2-restricted peptides from the viral structural proteins U54 and U11, and displayed various antigen-specific antiviral effector functions. These CD8(+) T cells specifically recognized HHV-6B-infected primary CD4(+) T cells in an HLA-restricted manner, produced antiviral cytokines, and killed infected cells, whereas HHV-6A-infected cells were not recognized. Thus, HHV-6B-specific CD8(+) T cells are likely to contribute to control of infection, overcoming the immunomodulatory effects exerted by the virus. Potentially, HHV-6-associated disease could be addressed by active or passive immunotherapy that reconstitutes virus-specific CD8(+) T-cell responses.
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Similar articles
-
Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells.J Virol. 2019 Jun 14;93(13):e02321-18. doi: 10.1128/JVI.02321-18. Print 2019 Jul 1. J Virol. 2019. PMID: 30996090 Free PMC article.
-
Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes.Eur J Immunol. 2014 Dec;44(12):3573-84. doi: 10.1002/eji.201444931. Epub 2014 Oct 29. Eur J Immunol. 2014. PMID: 25243920 Clinical Trial.
-
Cross-sectional analysis of CD8 T cell immunity to human herpesvirus 6B.PLoS Pathog. 2018 Apr 26;14(4):e1006991. doi: 10.1371/journal.ppat.1006991. eCollection 2018 Apr. PLoS Pathog. 2018. PMID: 29698478 Free PMC article.
-
HHV-6 and the immune system: mechanisms of immunomodulation and viral escape.J Clin Virol. 2006 Dec;37 Suppl 1:S4-10. doi: 10.1016/S1386-6532(06)70004-X. J Clin Virol. 2006. PMID: 17276368 Review.
-
Molecular biology of human herpesviruses 6A and 6B.Infect Agents Dis. 1993 Dec;2(6):343-60. Infect Agents Dis. 1993. PMID: 8012736 Review.
Cited by
-
Identification of CD4 and H-2Kd-restricted cytotoxic T lymphocyte epitopes on the human herpesvirus 6B glycoprotein Q1 protein.Sci Rep. 2019 Mar 7;9(1):3911. doi: 10.1038/s41598-019-40372-5. Sci Rep. 2019. PMID: 30846739 Free PMC article.
-
Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells.J Virol. 2019 Jun 14;93(13):e02321-18. doi: 10.1128/JVI.02321-18. Print 2019 Jul 1. J Virol. 2019. PMID: 30996090 Free PMC article.
-
Development of virus-specific CD4+ and CD8+ regulatory T cells induced by human herpesvirus 6 infection.J Virol. 2014 Jan;88(2):1011-24. doi: 10.1128/JVI.02586-13. Epub 2013 Nov 6. J Virol. 2014. PMID: 24198406 Free PMC article.
-
Advances in the Characterization of the T-Cell Response to Human Herpesvirus-6.Front Immunol. 2018 Jun 25;9:1454. doi: 10.3389/fimmu.2018.01454. eCollection 2018. Front Immunol. 2018. PMID: 29988505 Free PMC article. Review.
-
Human Herpesvirus 6B Downregulates Expression of Activating Ligands during Lytic Infection To Escape Elimination by Natural Killer Cells.J Virol. 2016 Oct 14;90(21):9608-9617. doi: 10.1128/JVI.01164-16. Print 2016 Nov 1. J Virol. 2016. PMID: 27535049 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials
