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. 2012 May;2(2):117-124.
doi: 10.1159/000337082. Epub 2012 Mar 20.

Chronic Inflammation and Coronary Atherosclerosis in Patients with End-Stage Renal Disease

Maen B Nusair  1 , Naveen Rajpurohit, Martin A Alpert
Affiliations

Chronic Inflammation and Coronary Atherosclerosis in Patients with End-Stage Renal Disease

Maen B Nusair et al. Cardiorenal Med. 2012 May.

Abstract

The key role of chronic inflammation in the pathogenesis of atherosclerosis has become increasingly apparent in recent years based on the results of experimental, epidemiologic and clinical studies. Coronary artery disease and its complications occur with disproportionately high frequency in patients with end-stage renal disease (ESRD) and contribute substantially to cardiovascular morbidity and mortality in this population. Traditional cardiovascular risk factors occur commonly in patients with ESRD. In addition, a variety of patient-related and dialysis-related factors unique to ESRD predispose to chronic inflammation and by doing so are thought to contribute to coronary atherosclerosis and its complications. These risk factors may serve as therapeutic targets and as such may offer the potential for altering the natural history of coronary atherosclerosis in ESRD.

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Figures

Fig. 1
Fig. 1
Mechanisms by which traditional cardiovascular risk factors combine with risk factors for chronic inflammation to lead to accelerated atherosclerosis. Traditional cardiovascular risk factors combine with uremia and dialysis-related risk factors to cause endothelial dysfunction and pro-inflammatory cytokine release. This stimulates production of acute phase reactants (CRP, serum amyloid A, fibrinogen) ultimately leading to accelerated atherosclerosis.
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