The gut microbiota, environment and diseases of modern society

doi:10.4161/gmic.21333

Review

. 2012 Jul-Aug;3(4):374-82.

doi: 10.4161/gmic.21333. Epub 2012 Jul 1.

The gut microbiota, environment and diseases of modern society

Judith R Kelsen¹, Gary D Wu

Affiliations

PMID: 22825455
PMCID: PMC3463495
DOI: 10.4161/gmic.21333

Review

The gut microbiota, environment and diseases of modern society

Judith R Kelsen et al. Gut Microbes. 2012 Jul-Aug.

. 2012 Jul-Aug;3(4):374-82.

doi: 10.4161/gmic.21333. Epub 2012 Jul 1.

Authors

Judith R Kelsen¹, Gary D Wu

Affiliation

¹ Children's Hospital of Philadelphia, Philadelphia, PA, USA.

PMID: 22825455
PMCID: PMC3463495
DOI: 10.4161/gmic.21333

Abstract

The human gut microbiota is a complex community that provides important metabolic functions to the host. Consequently, alterations in the gut microbiota have been associated with the pathogenesis of several human diseases associated with a disturbance in metabolism, particularly those that have been increasing in incidence over the last several decades including obesity, diabetes and atherosclerosis. In this review, we explore how advances in deep DNA sequencing technology have provided us a greater understanding of the factors that influence that composition of the gut microbiota and its possible links to the pathogenesis of these diseases.

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References

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[1] Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. MetaHIT Consortium. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65. doi: 10.1038/nature08821. - DOI - PMC - PubMed

[2] Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. MetaHIT Consortium. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464:59–65. doi: 10.1038/nature08821. - DOI - PMC - PubMed

[3] Lozupone CA, Knight R. Species divergence and the measurement of microbial diversity. FEMS Microbiol Rev. 2008;32:557–78. doi: 10.1111/j.1574-6976.2008.00111.x. - DOI - PMC - PubMed

[4] Lozupone CA, Knight R. Species divergence and the measurement of microbial diversity. FEMS Microbiol Rev. 2008;32:557–78. doi: 10.1111/j.1574-6976.2008.00111.x. - DOI - PMC - PubMed

[5] Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326:1694–7. doi: 10.1126/science.1177486. - DOI - PMC - PubMed

[6] Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326:1694–7. doi: 10.1126/science.1177486. - DOI - PMC - PubMed

[7] Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol. 2011;9:27–38. doi: 10.1038/nrmicro2473. - DOI - PubMed

[8] Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol. 2011;9:27–38. doi: 10.1038/nrmicro2473. - DOI - PubMed

[9] Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science. 2001;292:1115–8. doi: 10.1126/science.1058709. - DOI - PubMed

[10] Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science. 2001;292:1115–8. doi: 10.1126/science.1058709. - DOI - PubMed

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The gut microbiota, environment and diseases of modern society

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The gut microbiota, environment and diseases of modern society

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