Review
doi: 10.1007/BF01210407.
Reaction of thiyl radicals with alcohols, ethers and polyunsaturated fatty acids: a possible role of thiyl free radicals in thiol mutagenesis?
Affiliations
- PMID: 2281133
- DOI: 10.1007/BF01210407
Item in Clipboard
Review
Reaction of thiyl radicals with alcohols, ethers and polyunsaturated fatty acids: a possible role of thiyl free radicals in thiol mutagenesis?
Radiat Environ Biophys.
1990.
Abstract
Possible reactions of thiyl free radicals in biological environment are reviewed. In particular hydrogen transfer processes from model C-H compounds like alcohols and ethers as well as from polyunsaturated fatty acids to thiyl radicals are described to proceed with reasonably high rate constants (10(3)-10(4) and 10(6)-10(7) M-1 s-1, respectively). Thiyl radicals have thus to be considered as potentially hazardous species especially with respect to DNA damage and lipid peroxidation.
Comment in
-
Hand hygiene does work.Lancet Infect Dis. 2012 Nov;12(11):828-9. doi: 10.1016/S1473-3099(12)70235-9. Lancet Infect Dis. 2012. PMID: 23099078 No abstract available.
Similar articles
-
Hand hygiene does work.Lancet Infect Dis. 2012 Nov;12(11):828-9. doi: 10.1016/S1473-3099(12)70235-9. Lancet Infect Dis. 2012. PMID: 23099078 No abstract available.
-
Thiyl radical attack on polyunsaturated fatty acids: a possible route to lipid peroxidation.Biochem Biophys Res Commun. 1989 May 30;161(1):113-20. doi: 10.1016/0006-291x(89)91568-4. Biochem Biophys Res Commun. 1989. PMID: 2567162
-
Oxidation of polyunsaturated fatty acids and lipids through thiyl and sulfonyl radicals: reaction kinetics, and influence of oxygen and structure of thiyl radicals.Arch Biochem Biophys. 1992 Feb 1;292(2):456-67. doi: 10.1016/0003-9861(92)90016-p. Arch Biochem Biophys. 1992. PMID: 1731611
-
Thiyl radicals in biosystems: effects on lipid structures and metabolisms.Cell Mol Life Sci. 2005 Apr;62(7-8):834-47. doi: 10.1007/s00018-005-4475-y. Cell Mol Life Sci. 2005. PMID: 15868408 Review.
-
Thiyl radicals in biological systems: significant or trivial?Biochem Soc Symp. 1995;61:55-63. doi: 10.1042/bss0610055. Biochem Soc Symp. 1995. PMID: 8660403 Review.
Cited by
-
Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.J Phys Chem B. 2011 Oct 27;115(42):12287-305. doi: 10.1021/jp2070453. Epub 2011 Sep 30. J Phys Chem B. 2011. PMID: 21895001 Free PMC article.
-
The Reactive Sulfur Species Concept: 15 Years On.Antioxidants (Basel). 2017 May 23;6(2):38. doi: 10.3390/antiox6020038. Antioxidants (Basel). 2017. PMID: 28545257 Free PMC article. Review.
-
Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm.Antioxidants (Basel). 2022 Jul 13;11(7):1359. doi: 10.3390/antiox11071359. Antioxidants (Basel). 2022. PMID: 35883850 Free PMC article. Review.
-
Polarity-Driven Thiyl Radical-Catalyzed Aerobic Debenzylation of Ethers and Amines.J Org Chem. 2024 Oct 18;89(20):15062-15067. doi: 10.1021/acs.joc.4c01796. Epub 2024 Oct 9. J Org Chem. 2024. PMID: 39380545 Free PMC article.
References
-
- Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Oct;52(4):589-602 - PubMed
-
- Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Jan;51(1):91-102 - PubMed
-
- Biochem Biophys Res Commun. 1982 Jul 16;107(1):279-85 - PubMed
-
- Mutat Res. 1989 Sep;224(1):89-94 - PubMed
-
- Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Jun;41(6):595-602 - PubMed