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Editorial
. 2012 Aug 1;11(15):2769-70.
doi: 10.4161/cc.21257. Epub 2012 Aug 1.

Two new kinases in the TOR signaling network regulate ribosome and tRNA synthesis

Ian M Willis, Jaehoon Lee
Editorial

Two new kinases in the TOR signaling network regulate ribosome and tRNA synthesis

Ian M Willis et al. Cell Cycle. .

Abstract

Comment on: Lee J, et al. Mol Cell 2012; 45:836-43.

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Figures

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Figure 1. Network architecture model for TOR complex 1 regulation of tRNA gene transcription. The data suggest that signaling kinases downstream of TORC1 function in separate branched pathways to control the repressing function of Maf1 and the ability of pol III to be repressed by Maf1. Robust repression of tRNA gene transcription requires both branches and is represented by an AND-gated feedforward loop.
See this image and copyright information in PMC

Comment in

  • Lee J, Moir RD, McIntosh KB, Willis IM. TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases. Mol Cell. 2012;45:836–43. doi: 10.1016/j.molcel.2012.01.018.

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