Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or "Old Hat"?
- PMID: 22793158
- DOI: 10.1517/14728222.2012.708025
Anaerobic Pseudomonas aeruginosa and other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or "Old Hat"?
Abstract
Introduction: The cystic fibrosis (CF) airway mucus is an ideal niche in which many bacteria can develop antibiotic- and phagocyte-resistance in unique structures known as "mode II biofilms" where bacteria are embedded within the mucus, yet unattached to airway epithelial cells. Pseudomonas aeruginosa is the dominant CF pathogen, yet herein the authors provide burgeoning evidence that obligate anaerobic bacteria (e.g., Prevotella) actually thrive within the CF mucus, a paradigmatic shift that chronic CF is an "aerobic" disease. Interestingly, CF organisms repress virulence factor production (e.g., P. aeruginosa) while others (e.g., S. aureus) increase them under anaerobic conditions.
Areas covered: The authors shed additional light on (i) the anoxic nature of the CF airway mucus, (ii) the relative commonality of anaerobic bacteria isolated from CF sputum, (iii) virulence factor production and cross-talk between obligate anaerobes and P. aeruginosa relative to disease progression/remission, (iv) the role of mucoidy in CF, and (v) the role of nitrosative stress in activation of bacteriophage and pyocins within biofilms.
Expert opinion: The authors conclude with insight as to how we might treat some CF bacteria during mode II biofilm infections that utilizes a metabolite of bacterial anaerobic respiration and an aerobic oxidation product of airway-generated NO, acidified NO(2)(-).
Similar articles
-
Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways.Trends Microbiol. 2009 Mar;17(3):130-8. doi: 10.1016/j.tim.2008.12.003. Epub 2009 Feb 21. Trends Microbiol. 2009. PMID: 19231190 Review.
-
Antibiotic susceptabilities of Pseudomonas aeruginosa isolates derived from patients with cystic fibrosis under aerobic, anaerobic, and biofilm conditions.J Clin Microbiol. 2005 Oct;43(10):5085-90. doi: 10.1128/JCM.43.10.5085-5090.2005. J Clin Microbiol. 2005. PMID: 16207967 Free PMC article.
-
Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.Adv Drug Deliv Rev. 2002 Dec 5;54(11):1425-43. doi: 10.1016/s0169-409x(02)00152-7. Adv Drug Deliv Rev. 2002. PMID: 12458153 Review.
-
Competition in Biofilms between Cystic Fibrosis Isolates of Pseudomonas aeruginosa Is Shaped by R-Pyocins.mBio. 2019 Jan 29;10(1):e01828-18. doi: 10.1128/mBio.01828-18. mBio. 2019. PMID: 30696740 Free PMC article.
-
Pseudomonas aeruginosa biofilms in cystic fibrosis.Future Microbiol. 2010 Nov;5(11):1663-74. doi: 10.2217/fmb.10.125. Future Microbiol. 2010. PMID: 21133688 Review.
Cited by
-
Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation.mBio. 2015 Jul 28;6(4):e00767. doi: 10.1128/mBio.00767-15. mBio. 2015. PMID: 26220964 Free PMC article.
-
Olive Leaf Extract Modulates Quorum Sensing Genes and Biofilm Formation in Multi-Drug Resistant Pseudomonas aeruginosa.Antibiotics (Basel). 2020 Aug 19;9(9):526. doi: 10.3390/antibiotics9090526. Antibiotics (Basel). 2020. PMID: 32824901 Free PMC article.
-
Catalase (KatA) plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa.PLoS One. 2014 Mar 24;9(3):e91813. doi: 10.1371/journal.pone.0091813. eCollection 2014. PLoS One. 2014. PMID: 24663218 Free PMC article.
-
BdlA, DipA and induced dispersion contribute to acute virulence and chronic persistence of Pseudomonas aeruginosa.PLoS Pathog. 2014 Jun 5;10(6):e1004168. doi: 10.1371/journal.ppat.1004168. eCollection 2014 Jun. PLoS Pathog. 2014. PMID: 24901523 Free PMC article.
-
Histological assessment, anti-quorum sensing, and anti-biofilm activities of Dioon spinulosum extract: in vitro and in vivo approach.Sci Rep. 2022 Jan 7;12(1):180. doi: 10.1038/s41598-021-03953-x. Sci Rep. 2022. PMID: 34996996 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
