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. 2012:2012:960758.
doi: 10.1155/2012/960758. Epub 2012 Jun 24.

Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice

O T Soniran  1 , O A Idowu, O L Ajayi, I C Olubi
Affiliations

Comparative Study on the Effects of Chloroquine and Artesunate on Histopathological Damages Caused by Plasmodium berghei in Four Vital Organs of Infected Albino Mice

O T Soniran et al. Malar Res Treat. 2012.

Abstract

The aim of the present study was to investigate the positive influence of chloroquine and artesunate on the pathological damages caused by Plasmodium berghei on vital organs of mice in an established infection. Healthy adult albino mice with average weight of 25 g were used for the study. Treated group was administered orally with 100 mg/kg of chloroquine and artesunate, respectively. Control animals were given water for the same period. Histological examination of the liver, spleen, lungs, and kidney revealed absence of accumulation of iron (haemosiderosis) in the liver, thickened alveolar wall, and interstitial mononuclear cells infiltration in the lungs of the artesunate group, while absence of emphysema in the lungs and megakaryoblast hyperplasia in the spleen was observed in the chloroquine group. Lymphoid hypoplasia in the chloroquine group and megakayoblast hyperplasia in the artesunate group were observed but not in the control group. Thus, the use of these drugs especially under the practice of self-medication should be prohibited in lands where they are still in use as antimalaria medicine.

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Figures

Figure 1
Figure 1
LS of control liver and treated liver under high magnification (40x). (a) Control (infected without treatment) liver: showing severe hepatic necrosis with kupffer cells hyperplasia and haemosiderosis; (b) treated (artesunate) liver: showing mild hepatic necrosis and traces of periportal mononuclear cells infiltration; (c) treated (chloroquine) liver: showing mild haemosiderosis, kupffer cell hyperplasia, and hepatic necrosis, with traces of periportal mononuclear cells infiltration; (d) control (uninfected normal) liver.
Figure 2
Figure 2
L.S. of control spleen and treated spleen under high magnification (40x). (a) Control (infected without treatment) spleen: showing severe haemosiderosis; (b) treated (artesunate) spleen: showing mild haemosiderosis and severe megakamyoblast hyperplasia; (c) treated (chloroquine) spleen: showing mild haemosiderosis and lymphoid hypoplasia; (d) control (uninfected normal) spleen.
Figure 3
Figure 3
LS of control kidney and treated kidney under high magnification (40x). (a) Control (infected without treatment) kidney: showing severe tubular nephrosis and perivascular interstitial mononuclear cell infiltration; (b) Treated (artesunate) kidney: showing mild pathological changes; (c) treated (chloroquine) kidney: showing mild pathological changes; (d) control (uninfected normal) kidney.
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References

    1. African Medical and Research Foundation (17/062012) Malaria. New York, NY, USA: http://www.usa.amref.org/
    1. Obianime AW, Aprioku JS. Comparative study of artesunate, acts and their combinants on the hormonal parameters of the male guinea-pig. Nigerian Journal of Physiological Sciences. 2009;24(2):101–106. - PubMed
    1. Izunya AM, Nwaopara AO, Aigbiremolen AE, Odike MAC, Oaikhena GA, Bankole JK. Histological studies of the toxicity of artesunate on the testes in Wistar rats. Biology and Medicine. 2010;2(2):49–56.
    1. Drury RAB, Wallington EA, Cameron R. Carleton's Histological Techniques. 4th edition. New York, NY, USA: Oxford University; 1967.
    1. World Heath Organization. Media Centre on Malaria: Fact sheet, 2010, http://www.who.int/mediacentre/factsheets/fs094/en/index.html.

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