GAG layer replenishment therapy for chronic forms of cystitis with intravesical glycosaminoglycans--a review
- PMID: 22782909
- DOI: 10.1002/nau.22256
GAG layer replenishment therapy for chronic forms of cystitis with intravesical glycosaminoglycans--a review
Abstract
Aims: Glycosaminoglycan (GAG) layer replenishment is a cornerstone in the therapy of interstitial cystitis (IC). During the last years intravesical GAG layer replenishment has proven to be an effective treatment for overactive bladder (OAB), radiation cystitis, and recurrent urinary tract infections (UTIs).
Methods: Examination of different substances available for intravesical GAG replenishment and evaluation of the evidence for the treatment of the above-mentioned conditions.
Results: We searched the Medical Literature Analysis and Retrieval System Online (MEDLINE) database for studies on intravesical GAG replenishment. A total of 27 clinical studies remain relevant to this topic, many of them with mixed patient selection and suboptimal definition of symptom improvement/success. Two placebo controlled studies with hyaluronic acid failed to show superiority and have not been published. One active controlled randomized study has been published showing that chondroitin sulphate 0.2% has a clear benefit for OAB patients. Another study with chondroitin sulphate 2.0% failed to show statistically significant evidence, but was underpowered.
Conclusions: A short number of randomized controlled studies confirm efficacy of intravesical GAG layer replenishment therapy. Concluded from the study background (which comprises also uncontrolled studies), so far chondroitin sulphate 0.2% is in favor for intravesical GAG layer replenishment therapy. In general, large-scale trials are urgently needed to underline the benefit of this type of therapy.
Copyright © 2012 Wiley Periodicals, Inc.
Similar articles
-
Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial.Arzneimittelforschung. 2008;58(7):328-35. doi: 10.1055/s-0031-1296515. Arzneimittelforschung. 2008. PMID: 18751498
-
Intravesical glycosaminoglycans in the management of chronic cystitis.Minerva Urol Nefrol. 2013 Dec;65(4):249-62. Minerva Urol Nefrol. 2013. PMID: 24091478 Review.
-
A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis.BJU Int. 2009 Jan;103(1):56-60. doi: 10.1111/j.1464-410X.2008.08028.x. Epub 2008 Sep 3. BJU Int. 2009. PMID: 18778342 Clinical Trial.
-
GAG replenishment therapy for bladder pain syndrome/interstitial cystitis.Neurourol Urodyn. 2019 Feb;38(2):535-544. doi: 10.1002/nau.23900. Epub 2018 Dec 28. Neurourol Urodyn. 2019. PMID: 30592544 Review.
-
[Available evidence about efficacy of different restoring agents of glycosaminoglycans for intravesical use in interstitial cystitis].Actas Urol Esp. 2013 Feb;37(2):92-9. doi: 10.1016/j.acuro.2012.10.002. Epub 2012 Dec 20. Actas Urol Esp. 2013. PMID: 23260184 Review. Spanish.
Cited by
-
Glycosaminoglycan Replacement Therapy with Intravesical Instillations of Combined Hyaluronic Acid and Chondroitin Sulfate in Patients with Recurrent Cystitis, Post-radiation Cystitis and Bladder Pain Syndrome: A Narrative Review.Pain Ther. 2024 Feb;13(1):1-22. doi: 10.1007/s40122-023-00559-1. Epub 2023 Nov 2. Pain Ther. 2024. PMID: 37917298 Free PMC article. Review.
-
The efficacy and safety of intravesical chondroitin sulphate solution in recurrent urinary tract infections.BMC Urol. 2022 Nov 23;22(1):188. doi: 10.1186/s12894-022-01149-7. BMC Urol. 2022. PMID: 36424583 Free PMC article.
-
Role of oral pentosan polysulfate in Bacillus Calmette-Guérin therapy in patients with non-muscle-invasive bladder cancer.Investig Clin Urol. 2022 Sep;63(5):539-545. doi: 10.4111/icu.20220179. Investig Clin Urol. 2022. PMID: 36067999 Free PMC article.
-
Intravesical hyaluronic acid with chondroitin sulphate to prevent urinary tract infection after spinal cord injury.J Spinal Cord Med. 2023 Sep;46(5):830-836. doi: 10.1080/10790268.2022.2089816. Epub 2022 Jul 6. J Spinal Cord Med. 2023. PMID: 35792831 Free PMC article.
-
Urinary Tract Infection in Parkinson's Disease.J Parkinsons Dis. 2022;12(3):743-757. doi: 10.3233/JPD-213103. J Parkinsons Dis. 2022. PMID: 35147552 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources