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Editorial
. 2012 Jul 15;11(14):2585-6.
doi: 10.4161/cc.21138. Epub 2012 Jul 15.

Wnt signaling regulates experience-dependent synaptic plasticity in the adult nervous system

Michael Jensen, Penelope J Brockie, Andres V Maricq
Editorial

Wnt signaling regulates experience-dependent synaptic plasticity in the adult nervous system

Michael Jensen et al. Cell Cycle. .

Abstract

Comment on: Jensen M, et al. Cell 2012; 149:173-87.

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Figures

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Figure 1. Wnt signaling in the adult C. elegans nervous system is required for activity-dependent synaptic plasticity. (A) Motor neurons release CWN-2/Wnt5a, which binds to a novel heteromeric receptor composed of CAM-1/Ror receptor tyrosine kinase and LIN-17/Frizzled. Depending on motor neuron activity, MIG-14 mediated CWN-2 release can lead to a rapid, DSH-1/disheveled-dependent translocation of ACR-16/α7 nicotinic receptors to the synapse and an increase in receptor-mediated current. (B) NMJ morphology is intact in Wnt signaling mutants (cwn-2, cam-1, lin-17 or dsh-1), and other classes of neurotransmitter receptor (GABARs, levamisole AChRs) are normally localized, but postsynaptic ACR-16/α7 nicotinic AChRs are reduced with an associated increase in intracellular accumulations of these receptors.
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Comment in

  • Jensen M, Hoerndli FJ, Brockie PJ, Wang R, Johnson E, Maxfield D, Francis MM, Madsen DM, Maricq AV. Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell. 2012;149:173–87. doi: 10.1016/j.cell.2011.12.038.

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