Pharmacological lifespan extension of invertebrates
- PMID: 22771382
- PMCID: PMC3552093
- DOI: 10.1016/j.arr.2012.06.006
Pharmacological lifespan extension of invertebrates
Abstract
There is considerable interest in identifying small, drug-like compounds that slow aging in multiple species, particularly in mammals. Such compounds may prove to be useful in treating and retarding age-related disease in humans. Just as invertebrate models have been essential in helping us understand the genetic pathways that control aging, these model organisms are also proving valuable in discovering chemical compounds that influence longevity. The nematode Caenorhabditis elegans has numerous advantages for such studies including its short lifespan and has been exploited by a number of investigators to find compounds that impact aging. Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies.
Copyright © 2012 Elsevier B.V. All rights reserved.
Similar articles
-
A pharmacological network for lifespan extension in Caenorhabditis elegans.Aging Cell. 2014 Apr;13(2):206-15. doi: 10.1111/acel.12163. Epub 2013 Nov 13. Aging Cell. 2014. PMID: 24134630 Free PMC article.
-
Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan.G3 (Bethesda). 2020 Feb 6;10(2):849-862. doi: 10.1534/g3.119.400618. G3 (Bethesda). 2020. PMID: 31879284 Free PMC article.
-
Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans.Biol Res. 2013;46(2):147-52. doi: 10.4067/S0716-97602013000200005. Biol Res. 2013. PMID: 23959012
-
Autophagy and ageing: insights from invertebrate model organisms.Ageing Res Rev. 2013 Jan;12(1):413-28. doi: 10.1016/j.arr.2012.05.001. Epub 2012 May 24. Ageing Res Rev. 2013. PMID: 22634332 Review.
-
Endocrine targets for pharmacological intervention in aging in Caenorhabditis elegans.Aging Cell. 2006 Feb;5(1):23-30. doi: 10.1111/j.1474-9726.2006.00186.x. Aging Cell. 2006. PMID: 16441840 Review.
Cited by
-
The ACE inhibitor captopril inhibits ACN-1 to control dauer formation and aging.Development. 2024 Feb 1;151(3):dev202146. doi: 10.1242/dev.202146. Epub 2024 Feb 12. Development. 2024. PMID: 38284547
-
Drosophila melanogaster as a Translational Model System to Explore the Impact of Phytochemicals on Human Health.Int J Mol Sci. 2023 Aug 29;24(17):13365. doi: 10.3390/ijms241713365. Int J Mol Sci. 2023. PMID: 37686177 Free PMC article. Review.
-
Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans.Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2216141120. doi: 10.1073/pnas.2216141120. Epub 2023 Jul 31. Proc Natl Acad Sci U S A. 2023. PMID: 37523525 Free PMC article.
-
Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill.Front Aging. 2021 Sep 8;2:741843. doi: 10.3389/fragi.2021.741843. eCollection 2021. Front Aging. 2021. PMID: 35821992 Free PMC article. Review.
-
Antiaging agents: safe interventions to slow aging and healthy life span extension.Nat Prod Bioprospect. 2022 May 9;12(1):18. doi: 10.1007/s13659-022-00339-y. Nat Prod Bioprospect. 2022. PMID: 35534591 Free PMC article. Review.
References
-
- Abbas S, Wink M. Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans. Planta Med. 2009;75:216–221. - PubMed
-
- Abbas S, Wink M. Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine. 2010;17:902–909. - PubMed
-
- Adachi H, Fujiwara Y, Ishii N. Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans. J Gerontol A Biol Sci Med Sci. 1998;53A:B240–B244. - PubMed
-
- Adachi H, Ishii N. Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2000;55:B280–285. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources