Epigenetic alterations in muscular disorders

doi:10.1155/2012/256892

. 2012:2012:256892.

doi: 10.1155/2012/256892. Epub 2012 Jun 18.

Epigenetic alterations in muscular disorders

Chiara Lanzuolo¹

Affiliations

PMID: 22761545
PMCID: PMC3385594
DOI: 10.1155/2012/256892

Epigenetic alterations in muscular disorders

Chiara Lanzuolo. Comp Funct Genomics. 2012.

. 2012:2012:256892.

doi: 10.1155/2012/256892. Epub 2012 Jun 18.

Author

Chiara Lanzuolo¹

Affiliation

¹ CNR Institute of Cellular Biology and Neurobiology, IRCCS Santa Lucia Foundation, Via Del Fosso di Fiorano 64, 00143 Rome, Italy.

PMID: 22761545
PMCID: PMC3385594
DOI: 10.1155/2012/256892

Abstract

Epigenetic mechanisms, acting via chromatin organization, fix in time and space different transcriptional programs and contribute to the quality, stability, and heritability of cell-specific transcription programs. In the last years, great advances have been made in our understanding of mechanisms by which this occurs in normal subjects. However, only a small part of the complete picture has been revealed. Abnormal gene expression patterns are often implicated in the development of different diseases, and thus epigenetic studies from patients promise to fill an important lack of knowledge, deciphering aberrant molecular mechanisms at the basis of pathogenesis and diseases progression. The identification of epigenetic modifications that could be used as targets for therapeutic interventions could be particularly timely in the light of pharmacologically reversion of pathological perturbations, avoiding changes in DNA sequences. Here I discuss the available information on epigenetic mechanisms that, altered in neuromuscular disorders, could contribute to the progression of the disease.

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References

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1. Campos EI, Reinberg D. Histones: annotating chromatin. Annual Review of Genetics. 2009;43:559–599. - PubMed
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[1] Beisel C, Paro R. Silencing chromatin: comparing modes and mechanisms. Nature Reviews Genetics. 2011;12(2):123–135. - PubMed

[2] Beisel C, Paro R. Silencing chromatin: comparing modes and mechanisms. Nature Reviews Genetics. 2011;12(2):123–135. - PubMed

[3] Campos EI, Reinberg D. Histones: annotating chromatin. Annual Review of Genetics. 2009;43:559–599. - PubMed

[4] Campos EI, Reinberg D. Histones: annotating chromatin. Annual Review of Genetics. 2009;43:559–599. - PubMed

[5] Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes and Development. 2011;25(10):1010–1022. - PMC - PubMed

[6] Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes and Development. 2011;25(10):1010–1022. - PMC - PubMed

[7] Lanzuolo C, Orlando V. The function of the epigenome in cell reprogramming. Cellular and Molecular Life Sciences. 2007;64(9):1043–1062. - PMC - PubMed

[8] Lanzuolo C, Orlando V. The function of the epigenome in cell reprogramming. Cellular and Molecular Life Sciences. 2007;64(9):1043–1062. - PMC - PubMed

[9] Mao YS, Zhang B, Spector DL. Biogenesis and function of nuclear bodies. Trends in Genetics. 2011;27(8):295–306. - PMC - PubMed

[10] Mao YS, Zhang B, Spector DL. Biogenesis and function of nuclear bodies. Trends in Genetics. 2011;27(8):295–306. - PMC - PubMed

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Epigenetic alterations in muscular disorders

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Epigenetic alterations in muscular disorders

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