Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012:2012:648207.
doi: 10.1155/2012/648207. Epub 2012 May 3.

Notch Signaling during Oogenesis in Drosophila melanogaster

Jingxia Xu  1 , Thomas Gridley
Affiliations

Notch Signaling during Oogenesis in Drosophila melanogaster

Jingxia Xu et al. Genet Res Int. 2012.

Abstract

The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism that is required for embryonic development, cell fate specification, and stem cell maintenance. Discovered and studied initially in Drosophila melanogaster, the Notch pathway is conserved and functionally active throughout the animal kingdom. In this paper, we summarize the biochemical mechanisms of Notch signaling and describe its role in regulating one particular developmental pathway, oogenesis in Drosophila.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Core components of the canonical Notch signaling pathway in Drosophila. The two Notch ligands encoded by the Serrate (Ser) and Delta (Dl) genes (upper cell) interact with an adjacent cell expressing the Notch receptor. The Notch receptor is proteolytically cleaved by a Furin protease in the Golgi and exists at the cell surface as a proteolytically cleaved heterodimer consisting of a large ectodomain and a membrane-tethered intracellular domain. The receptor/ligand interaction induces additional proteolytic cleavages by ADAM-family metalloproteases and the gamma-secretase complex in the membrane-tethered intracellular domain. The final cleavage, catalyzed by gamma-secretase, frees the Notch intracellular domain (NICD) from the cell membrane. NICD translocates to the nucleus, where it forms a complex with the Supressor of Hairless (Su(H)) protein, displacing a histone deacetylase (HDAc)/corepressor (CoR) complex from the Su(H) protein. Components of an activation complex such as the Mastermind (MAM) protein and histone acetyltransferases (HAc) are recruited to the NICD/Su(H) complex, leading to the transcriptional activation of Notch target genes.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science. 1999;284(5415):770–776. - PubMed
    1. Penton A, Leonard L, Spinner N. Notch signaling in human development and disease. Seminars in Cell & Developmental Biology. In press. - PMC - PubMed
    1. Ranganathan P, Weaver KL, Capobianco AJ. Notch signalling in solid tumours: a little bit of everything but not all the time. Nature Reviews Cancer. 2011;11(5):338–351. - PubMed
    1. Apelqvist A, Li H, Sommer L, et al. Notch signalling controls pancreatic cell differentiation. Nature. 1999;400(6747):877–881. - PubMed
    1. Zhu X, Zhang J, Tollkuhn J, et al. Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes and Development. 2006;20(19):2739–2753. - PMC - PubMed

LinkOut - more resources