AMP-activated protein kinase: new regulation, new roles?
- PMID: 22702974
- DOI: 10.1042/BJ20120546
AMP-activated protein kinase: new regulation, new roles?
Abstract
The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A prerequisite of living cells is that the concentration of ATP needs to be maintained at sufficiently high levels to sustain essential cellular functions. In eukaryotic cells, the AMPK (AMP-activated protein kinase) cascade is one of the systems that have evolved to ensure that energy homoeostasis is maintained. AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Once activated, AMPK phosphorylates a broad range of downstream targets, resulting in the overall effect of increasing ATP-producing pathways whilst decreasing ATP-utilizing pathways. Disturbances in energy homoeostasis underlie a number of disease states in humans, e.g. Type 2 diabetes, obesity and cancer. Reflecting its key role in energy metabolism, AMPK has emerged as a potential therapeutic target. In the present review we examine the recent progress aimed at understanding the regulation of AMPK and discuss some of the latest developments that have emerged in key areas of human physiology where AMPK is thought to play an important role.
Similar articles
-
Keeping the home fires burning: AMP-activated protein kinase.J R Soc Interface. 2018 Jan;15(138):20170774. doi: 10.1098/rsif.2017.0774. J R Soc Interface. 2018. PMID: 29343628 Free PMC article. Review.
-
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.Biochem Soc Trans. 2011 Jan;39(1):1-13. doi: 10.1042/BST0390001. Biochem Soc Trans. 2011. PMID: 21265739
-
AMP-activated protein kinase: nature's energy sensor.Nat Chem Biol. 2011 Jul 18;7(8):512-8. doi: 10.1038/nchembio.610. Nat Chem Biol. 2011. PMID: 21769098 Review.
-
AMPK signalling in health and disease.Curr Opin Cell Biol. 2017 Apr;45:31-37. doi: 10.1016/j.ceb.2017.01.005. Epub 2017 Feb 21. Curr Opin Cell Biol. 2017. PMID: 28232179 Review.
-
The regulation of AMP-activated protein kinase by upstream kinases.Int J Obes (Lond). 2008 Sep;32 Suppl 4:S55-9. doi: 10.1038/ijo.2008.124. Int J Obes (Lond). 2008. PMID: 18719600 Review.
Cited by
-
Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes.Biomol Ther (Seoul). 2016 Nov 1;24(6):581-588. doi: 10.4062/biomolther.2016.141. Biomol Ther (Seoul). 2016. PMID: 27737527 Free PMC article.
-
The pharmacology of nociceptor priming.Handb Exp Pharmacol. 2015;227:15-37. doi: 10.1007/978-3-662-46450-2_2. Handb Exp Pharmacol. 2015. PMID: 25846612 Free PMC article. Review.
-
AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the regulation of sperm motility.Asian J Androl. 2017 Nov-Dec;19(6):707-714. doi: 10.4103/1008-682X.185848. Asian J Androl. 2017. PMID: 27678462 Free PMC article.
-
AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension.Int J Mol Sci. 2022 Jun 1;23(11):6205. doi: 10.3390/ijms23116205. Int J Mol Sci. 2022. PMID: 35682884 Free PMC article. Review.
-
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019. Cell Metab. 2013. PMID: 24093679 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
