Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Jun 13;13(7):425-35.
doi: 10.1038/nrm3373.

Towards a molecular architecture of centriole assembly

Pierre Gönczy  1
Affiliations
Review

Towards a molecular architecture of centriole assembly

Pierre Gönczy. Nat Rev Mol Cell Biol. .

Abstract

The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, revealing a striking ninefold radial arrangement of microtubules. However, it is only recently that the molecular mechanisms governing centriole assembly have begun to emerge, including the elucidation of the crucial role of spindle assembly abnormal 6 (SAS-6) proteins in imparting the ninefold symmetry. These advances have brought the field to an exciting era in which architecture meets function.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Curr Biol. 2009 Jun 23;19(12):1005-11 - PubMed
    1. Mol Biol Cell. 2009 Feb;20(4):1150-66 - PubMed
    1. J Biophys Biochem Cytol. 1960 Jul;7:697-716 - PubMed
    1. Cell Motil Cytoskeleton. 2009 Dec;66(12):1100-5 - PubMed
    1. J Cell Biol. 1967 Apr;33(1):73-92 - PubMed

Publication types

Substances

LinkOut - more resources