Review
doi: 10.1016/j.diff.2012.04.003.
Epub 2012 May 31.
TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken
Affiliations
- PMID: 22656450
- DOI: 10.1016/j.diff.2012.04.003
Item in Clipboard
Review
TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken
Differentiation.
2012 Jul.
Abstract
Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this process can lead to valvular and septal malformations, which constitute the largest part of congenital heart defects. One of the signaling pathways that is important for cushion formation is the TGFβ superfamily. The involvement of TGFβ and BMP signaling pathways in cardiac cushion formation has been intensively studied using chicken in vitro explant assays and in genetically modified mice. In this review, we will summarize and discuss the role of TGFβ and BMP signaling components in cardiac cushion formation.
Copyright © 2012 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.
Similar articles
-
Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice.Dev Biol. 2004 May 15;269(2):505-18. doi: 10.1016/j.ydbio.2004.01.045. Dev Biol. 2004. PMID: 15110716
-
Muscleblind-like 1 is required for normal heart valve development in vivo.BMC Dev Biol. 2015 Oct 15;15:36. doi: 10.1186/s12861-015-0087-4. BMC Dev Biol. 2015. PMID: 26472242 Free PMC article.
-
Roles of TGFbeta and BMP during valvulo-septal endocardial cushion formation.Anat Sci Int. 2009 Sep;84(3):77-87. doi: 10.1007/s12565-009-0027-0. Epub 2009 Mar 14. Anat Sci Int. 2009. PMID: 19288174 Review.
-
Expression and function of bone morphogenetic proteins in the development of the embryonic endocardial cushions.Anat Embryol (Berl). 2003 Sep;207(2):135-47. doi: 10.1007/s00429-003-0337-2. Epub 2003 Aug 1. Anat Embryol (Berl). 2003. PMID: 12905017
-
Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways.Mol Genet Metab. 2003 Sep-Oct;80(1-2):27-35. doi: 10.1016/j.ymgme.2003.07.004. Mol Genet Metab. 2003. PMID: 14567955 Review.
Cited by
-
Immobilization of murine anti-BMP-2 monoclonal antibody on various biomaterials for bone tissue engineering.Biomed Res Int. 2014;2014:940860. doi: 10.1155/2014/940860. Epub 2014 Jul 23. Biomed Res Int. 2014. PMID: 25147826 Free PMC article.
-
Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells.Commun Biol. 2021 Sep 6;4(1):1039. doi: 10.1038/s42003-021-02571-7. Commun Biol. 2021. PMID: 34489520 Free PMC article.
-
NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development.Oxid Med Cell Longev. 2020 Jun 16;2020:1679045. doi: 10.1155/2020/1679045. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32655758 Free PMC article.
-
Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis.Int J Mol Sci. 2022 Mar 4;23(5):2839. doi: 10.3390/ijms23052839. Int J Mol Sci. 2022. PMID: 35269981 Free PMC article. Review.
-
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.Sci Rep. 2018 Jun 22;8(1):9542. doi: 10.1038/s41598-018-27854-8. Sci Rep. 2018. PMID: 29934521 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
