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. 2012:2012:837375.
doi: 10.1155/2012/837375. Epub 2012 Apr 26.

Pregnancy followed by delivery may affect circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in women of reproductive age

Mehmet Balin  1 , Ahmet Çelik, M Ali Kobat, Adil Baydas
Affiliations

Pregnancy followed by delivery may affect circulating soluble lectin-like oxidized low-density lipoprotein receptor-1 levels in women of reproductive age

Mehmet Balin et al. Mediators Inflamm. 2012.

Abstract

Background/objective: It is known that menopause or lack of endogenous estrogen is a risk factor for endothelial dysfunction and CAD. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved inmultiple phases of vascular dysfunction. The purpose of the current study was to determine the association between soluble LOX-1 (sLOX-1) and pregnancy followed by delivery in women of reproductive age.

Materials/methods: Sixty-eight subjects with pregnancy followed by delivery (group 1) and 57 subjects with nongravidity (group 2) were included in this study. Levels of sLOX-1 were measured in serum by EL SA.

Results: Plasma levels of sLOX-1 were significantly lower in Group 1 than Group 2 in women of reproductive age (0.52 ± 0.18 ng/mL and 0.78 ± 0.13, resp., P < 0.001). There were strong correlations between sLOX-1 levels and the number of gravida (r = -0.645, P < 0.001). The levels of sLOX-1 highly correlated with the number of parous (r = -0.683, P < 0.001).

Conclusion: Our study demonstrated that serum sLOX-1 levels were associated with pregnancy followed by delivery that might predict endothelial dysfunction. We conclude that pregnancy followed by delivery may delay the beginning and progress of arteriosclerosis and its clinical manifestations in women of reproductive age.

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Figures

Figure 1
Figure 1
The comparison of sLOX-1 levels between two groups (Group 1: pregnancy followed by delivery group, Group 2: nongravidity group. Soluble LOX-1 levels were 0.78 ± 0.13 ng/mL in nongravidity group and 0.52 ± 0.18 ng/mL in pregnancy followed by delivery group, P < 0.001).
Figure 2
Figure 2
The correlation between sLOX-1 levels and number of gravida.
Figure 3
Figure 3
The correlation between sLOX-1 levels and number of parous.
See this image and copyright information in PMC

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References

    1. Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases—part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104(22):2746–2753. - PubMed
    1. Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction. Journal of the American College of Cardiology. 2005;46(7):1225–1228. - PubMed
    1. Witteman JC, Grobbee DE, Kok FJ, Hofman A, Valkenburg HA. Increased risk of atherosclerosis in women after the menopause. British Medical Journal. 1989;298(6674):642–644. - PMC - PubMed
    1. Barrett-Connor E. Sex differences in coronary heart disease: why are women so superior? The 1995 ancel keys lecture. Circulation. 1997;95(1):252–264. - PubMed
    1. Dubey RK, Imthurn B, Barton M, Jackson EK. Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen. Cardiovascular Research. 2005;66(2):295–306. - PubMed

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