Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1990 Dec;137(6):1273-81.

Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier

J L Madara  1
Affiliations
Review

Warner-Lambert/Parke-Davis Award lecture. Pathobiology of the intestinal epithelial barrier

J L Madara. Am J Pathol. 1990 Dec.

Abstract

The major route of passive permeation across intestinal epithelia is paracellular. The intercellular tight junction lies in and serves as the rate-limiting barrier in this paracellular pathway. Once viewed as static, it is now clear that the structure and permeability of the tight junction is highly dynamic. Not only may inflammatory events (cytokines, neutrophil transmigration) reversibly effect the tight junction but this key barrier also is regulated by physiologic events such as activation of absorptive cell Na(+)-nutrient cotransporters. Such physiologic regulation of the junction is of major importance to the absorption of nutrients via parcellular solvent drag.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Clin Invest. 1952 Oct;31(10):928-37 - PubMed
    1. J Cell Biol. 1980 Dec;87(3 Pt 1):746-54 - PubMed
    1. J Membr Biol. 1982;66(2):145-57 - PubMed
    1. Am J Physiol. 1987 Dec;253(6 Pt 1):C854-61 - PubMed
    1. Am J Physiol. 1987 Jul;253(1 Pt 1):C171-5 - PubMed

Publication types

LinkOut - more resources