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. 2012 Apr 28;4(4):174-8.
doi: 10.4329/wjr.v4.i4.174.

ARFI elastography for the evaluation of diffuse thyroid gland pathology: Preliminary results

Ioan Sporea  1 , Roxana Sirli, Simona Bota, Mihaela Vlad, Alina Popescu, Ioana Zosin
Affiliations

ARFI elastography for the evaluation of diffuse thyroid gland pathology: Preliminary results

Ioan Sporea et al. World J Radiol. .

Abstract

Aim: To assess whether acoustic radiation force impulse (ARFI) elastography can differentiate normal from pathological thyroid parenchyma.

Methods: We evaluated 136 subjects (mean age 45.8 ± 15.6 years, 106 women and 30 men): 44 (32.3%) without thyroid pathology, 48 (35.3%) with Basedow-Graves' disease (GD), 37 (27.2%) with chronic autoimmune thyroiditis (CAT; diagnosed by specific tests), 4 (2.9%) with diffuse thyroid goiter and 3 (2.2%) cases with thyroid pathology induced by amiodarone. In all patients, 10 elastographic measurements were made in the right thyroid lobe and 10 in the left thyroid lobe, using a 1-4.5 MHZ convex probe and a 4-9 MHz linear probe, respectively. Median values were calculated for thyroid stiffness and expressed in meters/second (m/s).

Results: Thyroid stiffness (TS) assessed by means of ARFI in healthy subjects (2 ± 0.40 m/s) was significantly lower than in GD (2.67 ± 0.53 m/s) (P < 0.0001) and CAT patients (2.43 ± 0.58 m/s) (P = 0.0002), but the differences were not significant between GD vs CAT patients (P = 0.053). The optimal cut-off value for the prediction of diffuse thyroid pathology was 2.36 m/s. For this cut-off value, TS had 62.5% sensitivity, 79.5% specificity, 87.6% predictive positive value, 55.5% negative predictive value and 72.7% accuracy for the presence of diffuse thyroid gland pathology (AUROC = 0.804). There were no significant differences between the TS values obtained with linear vs convex probes and when 5 vs 10 measurements were taken in each lobe (median values).

Conclusion: ARFI seems to be a useful method for the assessment of diffuse thyroid gland pathology.

Keywords: Acoustic radiation force impulse elastography; Thyroid pathology; Thyroid stiffness.

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Figures

Figure 1
Figure 1
Acoustic radiation force impulse measurement in the left thyroid lobe (with convex probe).
Figure 2
Figure 2
Mean thyroid stiffness values assessed by acoustic radiation force impulse elastography in healthy subjects vs patients with thyroid pathology. GD: Graves’ disease; CAT: Chronic autoimmune thyroiditis.
Figure 3
Figure 3
Mean thyroid stiffness values according to thyroid stimulating hormone levels. TSH: thyroid stimulating hormone.
See this image and copyright information in PMC

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References

    1. Nightingale K, Soo MS, Nightingale R, Trahey G. Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility. Ultrasound Med Biol. 2002;28:227–235. - PubMed
    1. Mauldin FW, Zhu HT, Behler RH, Nichols TC, Gallippi CM. Robust principal component analysis and clustering methods for automated classification of tissue response to ARFI excitation. Ultrasound Med Biol. 2008;34:309–325. - PMC - PubMed
    1. Ziol M, Handra-Luca A, Kettaneh A, Christidis C, Mal F, Kazemi F, de Lédinghen V, Marcellin P, Dhumeaux D, Trinchet JC, et al. Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. 2005;41:48–54. - PubMed
    1. Castéra L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M, Darriet M, Couzigou P, De Lédinghen V. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology. 2005;128:343–350. - PubMed
    1. Afdhal N. Debate: Are non-invasive tests ready to replace liver biopsy. favor of the use of non-invasive tests. Clinical Care Options. 2006:7–19.