Driving the cell cycle through metabolism
- PMID: 22578140
- DOI: 10.1146/annurev-cellbio-092910-154010
Driving the cell cycle through metabolism
Abstract
For unicellular organisms, the decision to enter the cell cycle can be viewed most fundamentally as a metabolic problem. A cell must assess its nutritional and metabolic status to ensure it can synthesize sufficient biomass to produce a new daughter cell. The cell must then direct the appropriate metabolic outputs to ensure completion of the division process. Herein, we discuss the changes in metabolism that accompany entry to, and exit from, the cell cycle for the unicellular eukaryote Saccharomyces cerevisiae. Studies of budding yeast under continuous, slow-growth conditions have provided insights into the essence of these metabolic changes at unprecedented temporal resolution. Some of these mechanisms by which cell growth and proliferation are coordinated with metabolism are likely to be conserved in multicellular organisms. An improved understanding of the metabolic basis of cell cycle control promises to reveal fundamental principles governing tumorigenesis, metazoan development, niche expansion, and many additional aspects of cell and organismal growth control.
Similar articles
-
How yeast coordinates metabolism, growth and division.Curr Opin Microbiol. 2018 Oct;45:1-7. doi: 10.1016/j.mib.2017.12.012. Epub 2018 Jan 13. Curr Opin Microbiol. 2018. PMID: 29334655 Review.
-
Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity.Science. 2007 Jun 29;316(5833):1916-9. doi: 10.1126/science.1140958. Science. 2007. PMID: 17600220
-
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.Annu Rev Genet. 2004;38:203-32. doi: 10.1146/annurev.genet.38.072902.093051. Annu Rev Genet. 2004. PMID: 15568976 Review.
-
Methods of Synchronization of Yeast Cells for the Analysis of Cell Cycle Progression.Methods Mol Biol. 2017;1505:19-34. doi: 10.1007/978-1-4939-6502-1_2. Methods Mol Biol. 2017. PMID: 27826853 Review.
-
Dynamic complex formation during the yeast cell cycle.Science. 2005 Feb 4;307(5710):724-7. doi: 10.1126/science.1105103. Science. 2005. PMID: 15692050
Cited by
-
Listeria monocytogenes Interferes with Host Cell Mitosis through Its Virulence Factors InlC and ActA.Toxins (Basel). 2020 Jun 20;12(6):411. doi: 10.3390/toxins12060411. Toxins (Basel). 2020. PMID: 32575670 Free PMC article.
-
The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing.Nat Commun. 2020 Aug 19;11(1):4154. doi: 10.1038/s41467-020-17961-4. Nat Commun. 2020. PMID: 32814778 Free PMC article.
-
The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma.Int J Mol Sci. 2018 Oct 18;19(10):3219. doi: 10.3390/ijms19103219. Int J Mol Sci. 2018. PMID: 30340359 Free PMC article. Review.
-
Cardiac metabolism in heart failure: implications beyond ATP production.Circ Res. 2013 Aug 30;113(6):709-24. doi: 10.1161/CIRCRESAHA.113.300376. Circ Res. 2013. PMID: 23989714 Free PMC article. Review.
-
Metabolomics analysis of an AAA-ATPase Cdc48-deficient yeast strain.Heliyon. 2023 Jan 24;9(2):e13219. doi: 10.1016/j.heliyon.2023.e13219. eCollection 2023 Feb. Heliyon. 2023. PMID: 36761826 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
