Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 May 11;12(6):411-24.
doi: 10.1038/nrc3264.

Killing a cancer: what are the alternatives?

Peter Kreuzaler  1 , Christine J Watson
Affiliations
Review

Killing a cancer: what are the alternatives?

Peter Kreuzaler et al. Nat Rev Cancer. .

Abstract

Evading programmed cell death is one of the hallmarks of cancer. Conversely, inducing cell death by pharmacological means is the basis of almost every non-invasive cancer therapy. Research over the past decade has greatly increased our understanding of non-apoptotic programmed cell death events, such as lysosomal-mediated cell death, necroptosis and cell death with autophagy. It is becoming clear that an intricate effector network connects many of these classical and non-classical death pathways. In this Review, we discuss converging and diverging features of these pathways, as well as attempts to exploit this newly gained knowledge pharmacologically to provide therapeutics for cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell. 2003 Jul 25;114(2):181-90 - PubMed
    1. J Clin Invest. 2000 Nov;106(9):1127-37 - PubMed
    1. Br J Haematol. 2010 May;149(4):529-36 - PubMed
    1. Surgery. 2011 Dec;150(6):1032-9 - PubMed
    1. Nature. 2000 Aug 24;406(6798):855-62 - PubMed

Publication types

Substances

LinkOut - more resources