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Review
. 2012 May 10;13(6):343-54.
doi: 10.1038/nrm3350.

TFIIH: when transcription met DNA repair

Emmanuel Compe  1 , Jean-Marc Egly
Affiliations
Review

TFIIH: when transcription met DNA repair

Emmanuel Compe et al. Nat Rev Mol Cell Biol. .

Erratum in

  • Nat Rev Mol Cell Biol. 2012 Jul;13(7):476

Abstract

The transcription initiation factor TFIIH is a remarkable protein complex that has a fundamental role in the transcription of protein-coding genes as well as during the DNA nucleotide excision repair pathway. The detailed understanding of how TFIIH functions to coordinate these two processes is also providing an explanation for the phenotypes observed in patients who bear mutations in some of the TFIIH subunits. In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'.

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