Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Apr 15;11(8):1486.
doi: 10.4161/cc.20048.

pRb or its cousins: who controls the family business?

Koji Itahana, Goberdhan P Dimri

pRb or its cousins: who controls the family business?

Koji Itahana et al. Cell Cycle. .

Abstract

Comment on: Bazarov A, et al. Cell Cycle 2012; 11:1008–1013

PubMed Disclaimer

Figures

None
Figure 1. Contribution of pRb family proteins to p16-mediated senescence in breast cancer cells and HMECs. Knockdown of each of the three pRb family proteins in breast cancer cells does not abrogate ectopic p16-induced senescence, suggesting that either two of pRb family proteins can compensate for the loss of each pRb family proteins or all three of pRb family proteins play an additive role in p16-mediated senescence in breast cancer cells. On the other hand, knockdown of pRb, but not of p107 or p130, abrogates HMEC senescence, suggesting a non-redundant critical role for pRb in senescence of HMECs. However, the knockdown of either p107 or p130, in conjunction with pRb depletion, abrogates HMEC senescence more efficiently than pRb knockdown alone. This suggests a supporting role for p107 and p130 in maintaining HMEC senescence.
See this image and copyright information in PMC

Comment in

  • Bazarov A, et al. The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells. Cell cycle. 2012;11 doi: 10.4161/cc.11.5.19492.

Similar articles

See all similar articles

References

    1. Stampfer MR, et al. Cancer Lett. 2003;194:199–208. doi: 10.1016/S0304-3835(02)00707-3. - DOI - PubMed
    1. Itahana K, et al. Mol Cell Biol. 2003;23:389–401. doi: 10.1128/MCB.23.1.389-401.2003. - DOI - PMC - PubMed
    1. Bazarov AV, et al. Cell Cycle. 2012;11:1008–13. doi: 10.4161/cc.11.5.19492. - DOI - PMC - PubMed
    1. Chicas A, et al. Cancer Cell. 2010;17:376–87. doi: 10.1016/j.ccr.2010.01.023. - DOI - PMC - PubMed
    1. Classon M, et al. Nat Rev Cancer. 2002;2:910–7. doi: 10.1038/nrc950. - DOI - PubMed

MeSH terms

Substances

LinkOut - more resources