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. 2012:2012:459087.
doi: 10.1155/2012/459087. Epub 2012 Mar 29.

Effects of restricted fructose access on body weight and blood pressure circadian rhythms

Danielle Senador  1 , Swapnil Shewale, Maria Claudia Irigoyen, Khalid M Elased, Mariana Morris
Affiliations

Effects of restricted fructose access on body weight and blood pressure circadian rhythms

Danielle Senador et al. Exp Diabetes Res. 2012.

Abstract

High-fructose diet is known to produce cardiovascular and metabolic pathologies. The objective was to determine whether the timing of high fructose (10% liquid solution) intake affect the metabolic and cardiovascular outcomes. Male C57BL mice with radiotelemetric probes were divided into four groups: (1) 24 h water (control); (2) 24 h fructose (F24); (3) 12 h fructose during the light phase (F12L); (4) 12 h fructose during the dark phase (F12D). All fructose groups had higher fluid intake. Body weight was increased in mice on restricted access with no difference in total caloric intake. Fasting glycemia was higher in groups with restricted access. F24 mice showed a fructose-induced blood pressure increase during the dark period. Blood pressure circadian rhythms were absent in F12L mice. Results suggest that the timing of fructose intake is an important variable in the etiology of cardiovascular and metabolic pathologies produced by high fructose consumption.

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Figures

Figure 1
Figure 1
Body weight gain as percentage increase from day 0 in control and fructose-treated groups. ANOVA showed main effect of time (F (2.6156) = 8.97.23, P < 0.0012). *P < 0.015 vs. 2 wks.
Figure 2
Figure 2
Daily total caloric intake and fructose percentage caloric intake in control and fructose-treated groups.
Figure 3
Figure 3
12 h fluid intake in control and fructose groups. ANOVA showed main effect of fructose diet [F (3.20) = 8.4, P < 0.001], light/dark (F (1.20) = 50.2, P < 0.00001) and interaction between diet and light/dark (F (3.20) = 5.7, P < 0.01). § P < 0.01 light vs. dark. *P < 0.01 versus Control.
Figure 4
Figure 4
(A) Fasting glycemia in control and fructose groups. F12L and F12D mice showed hyperglicemia ANOVA treatment (F (1.18) = 12.3, P < 0.0003). *P < 0.01 versus control. (B) Glucose tolerance test estimated by area under the time curve (AUC) in control and fructose-treated groups. F24 h and F12L mice showed impaired glucose tolerance. ANOVA treatment (F (1.16) = 4.9, P < 0.05). *P < 0.01 versus Control.
Figure 5
Figure 5
MAP (A) and HR (B) were recorded for 24 h and analyzed during 24 h light and dark phases. ANOVA showed main effect of light/dark for MAP (F (1.32) = 11.2, P < 0.005) and HR (F (1.32) = 16.62, P < 0.0003). § P < 0.05 light versus dark. *P < 0.05 versus Control.
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References

    1. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. The American Journal of Clinical Nutrition. 2002;76(5):911–922. - PubMed
    1. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. The American Journal of Clinical Nutrition. 2004;79(4):537–543. - PubMed
    1. Brown CM, Dulloo AG, Yepuri G, Montani JP. Fructose ingestion acutely elevates blood pressure in healthy young humans. American Journal of Physiology. 2008;294(3):R730–R737. - PubMed
    1. Farah V, Elased KM, Chen Y, et al. Nocturnal hypertension in mice consuming a high fructose diet. Autonomic Neuroscience. 2006;130(1-2):41–50. - PubMed
    1. Furuhashi M, Ura N, Takizawa H, et al. Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity. Journal of Hypertension. 2004;22(10):1977–1982. - PubMed

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