Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Aug;14(4):364-8.
doi: 10.1007/s11926-012-0255-5.

What have genome-wide studies told us about psoriatic arthritis?

James Bluett  1 , Anne Barton
Affiliations
Review

What have genome-wide studies told us about psoriatic arthritis?

James Bluett et al. Curr Rheumatol Rep. 2012 Aug.

Abstract

There is convincing evidence to suggest a strong genetic component to psoriatic arthritis (PsA), with studies reporting a 40-fold risk to first-degree relatives of patients with disease. However, compared with rheumatoid arthritis, our understanding of the genetic etiology of PsA is less well-developed. Only three modestly sized genome-wide association studies of PsA have been undertaken to date, but they have identified the HLA-C region, IL12B, TRAF3IP2, and FBXL19 genes as being associated with PsA susceptibility. Results of genome-wide association studies of psoriasis and rheumatoid arthritis have been used to identify candidate genes for subsequent testing in PsA and have led to the identification of additional susceptibility factors for PsA. Most show overlap with psoriasis, whereas the overlap with rheumatoid arthritis is less pronounced. However, two loci show strong evidence for association with PsA but not psoriasis: HLA-B27 and the IL-13 gene locus.

PubMed Disclaimer

Similar articles

  • Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
    Stuart PE, Nair RP, Tsoi LC, Tejasvi T, Das S, Kang HM, Ellinghaus E, Chandran V, Callis-Duffin K, Ike R, Li Y, Wen X, Enerbäck C, Gudjonsson JE, Kõks S, Kingo K, Esko T, Mrowietz U, Reis A, Wichmann HE, Gieger C, Hoffmann P, Nöthen MM, Winkelmann J, Kunz M, Moreta EG, Mease PJ, Ritchlin CT, Bowcock AM, Krueger GG, Lim HW, Weidinger S, Weichenthal M, Voorhees JJ, Rahman P, Gregersen PK, Franke A, Gladman DD, Abecasis GR, Elder JT. Stuart PE, et al. Am J Hum Genet. 2015 Dec 3;97(6):816-36. doi: 10.1016/j.ajhg.2015.10.019. Epub 2015 Nov 28. Am J Hum Genet. 2015. PMID: 26626624 Free PMC article.
  • Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.
    Aterido A, Cañete JD, Tornero J, Ferrándiz C, Pinto JA, Gratacós J, Queiró R, Montilla C, Torre-Alonso JC, Pérez-Venegas JJ, Fernández Nebro A, Muñoz-Fernández S, González CM, Roig D, Zarco P, Erra A, Rodríguez J, Castañeda S, Rubio E, Salvador G, Díaz-Torné C, Blanco R, Willisch Domínguez A, Mosquera JA, Vela P, Sánchez-Fernández SA, Corominas H, Ramírez J, de la Cueva P, Fonseca E, Fernández E, Puig L, Dauden E, Sánchez-Carazo JL, López-Estebaranz JL, Moreno D, Vanaclocha F, Herrera E, Blanco F, Fernández-Gutiérrez B, González A, Pérez-García C, Alperi-López M, Olivé Marques A, Martínez-Taboada V, González-Álvaro I, Sanmartí R, Tomás Roura C, García-Montero AC, Bonàs-Guarch S, Mercader JM, Torrents D, Codó L, Gelpí JL, López-Corbeto M, Pluma A, López-Lasanta M, Tortosa R, Palau N, Absher D, Myers R, Marsal S, Julià A. Aterido A, et al. Ann Rheum Dis. 2019 Mar;78(3):e214158. doi: 10.1136/annrheumdis-2018-214158. Epub 2018 Dec 14. Ann Rheum Dis. 2019. PMID: 30552173
  • The Genetics of Psoriasis and Psoriatic Arthritis.
    O'Rielly DD, Jani M, Rahman P, Elder JT. O'Rielly DD, et al. J Rheumatol Suppl. 2019 Jun;95:46-50. doi: 10.3899/jrheum.190119. J Rheumatol Suppl. 2019. PMID: 31154404
  • Genetics of psoriatic arthritis.
    O'Rielly DD, Rahman P. O'Rielly DD, et al. Best Pract Res Clin Rheumatol. 2014 Oct;28(5):673-85. doi: 10.1016/j.berh.2014.10.010. Epub 2014 Nov 22. Best Pract Res Clin Rheumatol. 2014. PMID: 25488777 Review.
  • The genetics of psoriatic arthritis: lessons from genome-wide association studies.
    Bowes J, Barton A. Bowes J, et al. Discov Med. 2010 Sep;10(52):177-83. Discov Med. 2010. PMID: 20875338 Review.
See all similar articles

Cited by

References

    1. Ann Rheum Dis. 2012 Jan;71(1):50-5 - PubMed
    1. Nat Genet. 2010 Nov;42(11):996-9 - PubMed
    1. Nat Genet. 2007 Dec;39(12):1431-3 - PubMed
    1. Nat Genet. 2010 Nov;42(11):1000-4 - PubMed
    1. N Engl J Med. 2011 Aug 18;365(7):620-8 - PubMed

Publication types

MeSH terms

LinkOut - more resources