Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Apr 1;16(2):63-77.
doi: 10.1007/BF03256431.

Molecular diagnosis and management of viral infections in hematopoietic stem cell transplant recipients

Sabine Breuer  1 , Margit Rauch, Susanne Matthes-Martin, Thomas Lion
Affiliations
Review

Molecular diagnosis and management of viral infections in hematopoietic stem cell transplant recipients

Sabine Breuer et al. Mol Diagn Ther. .

Abstract

Viral infections after allogeneic hematopoietic stem cell transplantation (HSCT) are important complications associated with high morbidity and mortality. In this setting, reactivations of persisting latent viral pathogens from donor and/or recipient cells play a central role whereas the sterile environment of transplant units renders new infections less likely. The viruses currently regarded as most relevant in the HSCT setting include particularly the herpes virus family--specifically cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus 6 (HHV-6)--as well as human adenoviruses (AdVs) and the polyoma virus BK (BKV). Timely detection and monitoring of virus copy numbers are prerequisites for successful preemptive treatment approaches. Pre- and post-transplant surveillance by sensitive and quantitative molecular methods has therefore become an essential part of the diagnostic routine. In this review, we discuss diagnostic aspects and the clinical management of the most important viral infections in HSCT recipients, with a focus on pediatric patients.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Br J Haematol. 2005 Aug;130(4):595-603 - PubMed
    1. Blood. 2003 Jan 15;101(2):407-14 - PubMed
    1. Clin Infect Dis. 2004 Jun 1;38(11):1521-5 - PubMed
    1. Pediatrics. 1993 Aug;92(2):219-22 - PubMed
    1. Lancet. 2003 Oct 25;362(9393):1375-7 - PubMed

MeSH terms

LinkOut - more resources