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. 2012 Mar 29;9(1):25.
doi: 10.1186/1743-7075-9-25.

Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

Wijtske Annema  1 , Uwe Jf Tietge
Affiliations

Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

Wijtske Annema et al. Nutr Metab (Lond). .

Abstract

Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included.

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