Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids
- PMID: 22455609
- DOI: 10.1021/jf3000373
Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids
Abstract
Assessment of the health effects of dietary interventions in humans poses a particular challenge to nutritional and clinical scientists. In contrast to drugs possessing a well-defined molecular mechanism of action, food-derived components act in subtle and pleiotropic ways by nature. Moreover, dietary compounds are mainly not intended to cure a disease but to prevent or beneficially affect situations when the physiology gets slightly out of homeostasis. By the example of a recent clinical pilot study, this paper illustrates an endeavor to find new strategies for the detection of health effects of flavonoids in the human vasculature. Integration of a meticulously selected cluster of relevant biomarkers eventually enabled the beneficial vascular health effects of flavonoids to be revealed. A critical appraisal of this approach for the future is provided.
Similar articles
-
Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Food Chem Toxicol. 2008. PMID: 18328408 Review.
-
[Dietary flavonoids and human health].Ann Pharm Fr. 2011 Mar;69(2):78-90. doi: 10.1016/j.pharma.2010.11.004. Epub 2011 Mar 1. Ann Pharm Fr. 2011. PMID: 21440100 Review. French.
-
Dietary PUFA and flavonoids as deterrents for environmental pollutants.J Nutr Biochem. 2007 Mar;18(3):196-205. doi: 10.1016/j.jnutbio.2006.12.002. J Nutr Biochem. 2007. PMID: 17296493 Review.
-
A clinical trial of troxerutin in venous insufficiency of the lower limb.Practitioner. 1967 Mar;198(185):406-7. Practitioner. 1967. PMID: 5341529 Clinical Trial. No abstract available.
-
Scavenging of peroxynitrite-derived radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetable intakes.Med Hypotheses. 2008;70(1):170-81. doi: 10.1016/j.mehy.2005.09.058. Epub 2007 Sep 6. Med Hypotheses. 2008. PMID: 17825500
Cited by
-
Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms.Int J Mol Sci. 2016 Feb 15;17(2):239. doi: 10.3390/ijms17020239. Int J Mol Sci. 2016. PMID: 26891295 Free PMC article.
-
Sulforaphane as a potential modifier of calorie-induced inflammation: a double-blind, placebo-controlled, crossover trial.Front Nutr. 2023 Nov 28;10:1245355. doi: 10.3389/fnut.2023.1245355. eCollection 2023. Front Nutr. 2023. PMID: 38089924 Free PMC article.
-
Nutrition to Optimise Human Health-How to Obtain Physiological Substantiation?Nutrients. 2021 Jun 23;13(7):2155. doi: 10.3390/nu13072155. Nutrients. 2021. PMID: 34201670 Free PMC article. Review.
-
Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease.J Geriatr Cardiol. 2017 May;14(5):355-368. doi: 10.11909/j.issn.1671-5411.2017.05.012. J Geriatr Cardiol. 2017. PMID: 28630615 Free PMC article. Review.
-
Can Natural Products Exert Neuroprotection without Crossing the Blood-Brain Barrier?Int J Mol Sci. 2021 Mar 25;22(7):3356. doi: 10.3390/ijms22073356. Int J Mol Sci. 2021. PMID: 33805947 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
