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. 2012:2012:171706.
doi: 10.1155/2012/171706. Epub 2012 Feb 12.

Traditional chinese herbal patch for short-term management of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial

Xuezong Wang  1 , Yuelong Cao, Jian Pang, Jiong Du, Chaoqing Guo, Ting Liu, Songpu Wei, Yuxin Zheng, Rongming Chen, Hongsheng Zhan
Affiliations

Traditional chinese herbal patch for short-term management of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial

Xuezong Wang et al. Evid Based Complement Alternat Med. 2012.

Abstract

Objective. To assess the short-term efficacy and safety of two kinds of Traditional Chinese herbal patches, Fufang Nanxing Zhitong Gao (FNZG) and Shangshi Jietong Gao (SJG), for painful knee osteoarthritis (OA). Methods. Patients were randomly enrolled in a double-blind, placebo-controlled study to receive FNZG (n = 60), SJG (n = 60), or placebo patch (n = 30) for 7 days. Outcome measures included visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Traditional Chinese Medicine Syndrome Questionnaire (TCMSQ) subscale. Results. Although there was no significant difference among, three groups in short-term pain management, patients receiving FNZG got significant improvement in symptom of fear of coldness as compared with placebo patch (P = 0.029). The most common local adverse events of rash, itching, erythema, and slightly damaged skin were observed in 7% of participants. Conclusions. FNZG may be a useful treatment for symptom of knee OA and merits long-term study in broader populations.

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Figures

Figure 1
Figure 1
Flow diagram of the trial progress about enrollment, randomization, intervention, and completion of 1-day and 7-day evaluations.
Figure 2
Figure 2
Mean changes of VAS score by treatment group during the 7-day intervention period.
See this image and copyright information in PMC

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