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Review
. 2012 Sep;53(1-3):213-28.
doi: 10.1007/s12026-012-8296-4.

Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma

Lakshmi Ramakrishna  1 , Victor Christoff de Vries, Maria Alicia Curotto de Lafaille
Affiliations
Review

Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma

Lakshmi Ramakrishna et al. Immunol Res. 2012 Sep.

Abstract

Allergic asthma is a chronic disease of the lung characterized by underlying Th2- and IgE-mediated inflammation, structural alterations of the bronchial wall, and airway hyperresponsiveness. Initial allergic sensitization and later development of chronic disease are determined by close interactions between lung structural cells and the resident and migratory immune cells in the lung. Epithelial cells play a crucial role in allergic sensitization by directly influencing dendritic cells induction of tolerant or effector T cells and production of type 2 cytokines by innate immune cells. During chronic disease, the bronchial epithelium, stroma, and smooth muscle become structurally and functionally altered, contributing to the perpetuation of tissue remodeling. Thus, targeting tissue-driven pathology in addition to inflammation may increase the effectiveness of asthma treatment.

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References

    1. Immunol Rev. 2011 Jul;242(1):186-204 - PubMed
    1. J Cell Sci. 2007 Mar 1;120(Pt 5):815-25 - PubMed
    1. J Immunol. 2009 Aug 1;183(3):1732-8 - PubMed
    1. J Biol Chem. 2005 Jan 21;280(3):2147-58 - PubMed
    1. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17723-8 - PubMed

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