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Review
. 2012 May 24;119(21):4823-7.
doi: 10.1182/blood-2011-12-353466. Epub 2012 Mar 13.

Hemogenic endothelium during development and beyond

Karen K Hirschi  1
Affiliations
Review

Hemogenic endothelium during development and beyond

Karen K Hirschi. Blood. .

Abstract

During embryonic development, multilineage HSCs/progenitor cells are derived from specialized endothelial cells, termed hemogenic endothelium, within the yolk sac, placenta, and aorta. Whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, such as in the fetal liver and fetal bone marrow, is not known. Also unknown is whether such cells exist within the vasculature of adult bone marrow and generate hematopoietic stem cells after birth. These issues and their clinical relevance are discussed herein.

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Figures

Figure 1
Figure 1
Development of yolk sac hemogenic endothelial cells.
Figure 2
Figure 2
Postnatal hemogenic endothelial cells?
See this image and copyright information in PMC

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References

    1. Silver L, Palis J. Initiation of murine embryonic erythropoiesis: a spatial analysis. Blood. 1997;89(4):1154–1164. - PubMed
    1. Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999;126(22):5073–5084. - PubMed
    1. Lucitti JL, Jones EA, Huang C, Chen J, Fraser SE, Dickinson ME. Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development. 2007;134(18):3317–3326. - PMC - PubMed
    1. Cumano A, Dieterlen-Lievre F, Godin I. Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell. 1996;86(6):907–916. - PubMed
    1. Gekas C, Dieterlen-Lievre F, Orkin SH, Mikkola HK. The placenta is a niche for hematopoietic stem cells. Dev Cell. 2005;8(3):365–375. - PubMed