Estimating recombination rates from genetic variation in humans
- PMID: 22399461
- DOI: 10.1007/978-1-61779-585-5_9
Estimating recombination rates from genetic variation in humans
Abstract
Recombination acts to shuffle the existing genetic variation within a population, leading to various approaches for detecting its action and estimating the rate at which it occurs. Here, we discuss the principal methodological and analytical approaches taken to understanding the distribution of recombination across the human genome. We first discuss the detection of recent crossover events in both well-characterised pedigrees and larger populations with extensive recent shared ancestry. We then describe approaches for learning about the fine-scale structure of recombination rate variation from patterns of genetic variation in unrelated individuals. Finally, we show how related approaches using individuals of admixed ancestry can provide an alternative approach to analysing recombination. Approaches differ not only in the statistical methods used, but also in the resolution of inference, the timescale over which recombination events are detected, and the extent to which inter-individual variation can be identified.
Similar articles
-
Corn and humans: recombination and linkage disequilibrium in two genomes of similar size.Trends Genet. 2004 Feb;20(2):103-11. doi: 10.1016/j.tig.2003.12.002. Trends Genet. 2004. PMID: 14746992 Review.
-
The extent, mechanism, and consequences of genetic variation, for recombination rate.Am J Hum Genet. 1996 Dec;59(6):1175-83. Am J Hum Genet. 1996. PMID: 8940261 Free PMC article. No abstract available.
-
Absence of the TAP2 human recombination hotspot in chimpanzees.PLoS Biol. 2004 Jun;2(6):e155. doi: 10.1371/journal.pbio.0020155. Epub 2004 Jun 15. PLoS Biol. 2004. PMID: 15208713 Free PMC article.
-
Fine-scale recombination patterns differ between chimpanzees and humans.Nat Genet. 2005 Apr;37(4):429-34. doi: 10.1038/ng1529. Epub 2005 Feb 18. Nat Genet. 2005. PMID: 15723063
-
Insights from linked single nucleotide polymorphisms: what we can learn from linkage disequilibrium.Curr Opin Genet Dev. 2001 Dec;11(6):647-51. doi: 10.1016/s0959-437x(00)00248-3. Curr Opin Genet Dev. 2001. PMID: 11682308 Review.
Cited by
-
Recommendations for improving statistical inference in population genomics.PLoS Biol. 2022 May 31;20(5):e3001669. doi: 10.1371/journal.pbio.3001669. eCollection 2022 May. PLoS Biol. 2022. PMID: 35639797 Free PMC article.
-
BREC: an R package/Shiny app for automatically identifying heterochromatin boundaries and estimating local recombination rates along chromosomes.BMC Bioinformatics. 2021 Aug 6;22(Suppl 6):396. doi: 10.1186/s12859-021-04233-1. BMC Bioinformatics. 2021. PMID: 34362304 Free PMC article.
-
Evolution of Recombination Landscapes in Diverging Populations of Bread Wheat.Genome Biol Evol. 2021 Aug 3;13(8):evab152. doi: 10.1093/gbe/evab152. Genome Biol Evol. 2021. PMID: 34185074 Free PMC article.
-
Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits.Genome Res. 2020 Dec;30(12):1802-1814. doi: 10.1101/gr.258301.119. Epub 2020 Nov 17. Genome Res. 2020. PMID: 33203765 Free PMC article.
-
Estimating Time to the Common Ancestor for a Beneficial Allele.Mol Biol Evol. 2018 Apr 1;35(4):1003-1017. doi: 10.1093/molbev/msy006. Mol Biol Evol. 2018. PMID: 29361025 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
