Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Aug;42(2):312-8.
doi: 10.1093/ejcts/ezs067. Epub 2012 Feb 29.

Mechanical unloading and cell therapy have a synergistic role in the recovery and regeneration of the failing heart

Michael Ibrahim  1 , Christopher Rao, Thanos Athanasiou, Magdi H Yacoub, Cesare M Terracciano
Affiliations
Review

Mechanical unloading and cell therapy have a synergistic role in the recovery and regeneration of the failing heart

Michael Ibrahim et al. Eur J Cardiothorac Surg. 2012 Aug.

Abstract

The problem of a growing patient population with end-stage heart failure and a fixed cardiac donor pool has stimulated the development of novel therapies for heart failure. Two therapeutic strategies have emerged with the potential to improve the landscape of the clinical management of heart failure. First, left ventricular assist device therapy is able to sustain the circulation of patients in end-stage heart failure and may promote cardiac recovery. Secondly, stem cell therapy can potentially be used to induce myocardial regeneration replacing lost or non-functioning native myocardium. In this review, we present evidence that these strategies may overlap significantly in their mechanisms of action at the systems, organ, tissue and cellular levels. We review the current clinical evidence of their combined use.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types