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. 2012:4.
doi: 10.3402/jom.v4i0.9929. Epub 2012 Feb 21.

Treponema denticola interactions with host proteins

J Christopher Fenno  1
Affiliations

Treponema denticola interactions with host proteins

J Christopher Fenno. J Oral Microbiol. 2012.

Abstract

Oral Treponema species, most notably T. denticola, are implicated in the destructive effects of human periodontal disease. Progress in the molecular analysis of interactions between T. denticola and host proteins is reviewed here, with particular emphasis on the characterization of surface-expressed and secreted proteins of T. denticola involved in interactions with host cells, extracellular matrix components, and components of the innate immune system.

Keywords: periodontal disease; spirochetes; virulence factors.

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Figures

Fig. 1
Fig. 1
Immunofluorescence micrograph showing T. denticola adherence to periodontal ligament cells. Periodontal ligament cell monolayers were challenged with T. denticola 35405 for 2 hours, then washed extensively with PBS before staining. Periodontal ligament cells are stained with phalloidin. T. denticola is visualized with Alexa-fluor-labeled antiMsp antibodies.
See this image and copyright information in PMC

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