Losing TREC with age

doi:10.1016/j.immuni.2012.02.005

Comment

. 2012 Feb 24;36(2):163-5.

doi: 10.1016/j.immuni.2012.02.005.

Losing TREC with age

Shirley L Zhang¹, Avinash Bhandoola

Affiliations

PMID: 22365662
PMCID: PMC4026262
DOI: 10.1016/j.immuni.2012.02.005

Comment

Losing TREC with age

Shirley L Zhang et al. Immunity. 2012.

. 2012 Feb 24;36(2):163-5.

doi: 10.1016/j.immuni.2012.02.005.

Authors

Shirley L Zhang¹, Avinash Bhandoola

Affiliation

¹ Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

PMID: 22365662
PMCID: PMC4026262
DOI: 10.1016/j.immuni.2012.02.005

Abstract

In this issue of Immunity, den Braber et al. (2012) highlight differences in naive T cell lifespan between mice and humans. Their data suggest that mechanisms of naive T cell maintenance may differ between mice and men.

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Figures

**Figure 1. Diagram of TREC content in naïve T cell populations**
The average TREC content of naïve T cells remains comparable in both young and old mice. In humans, TREC content of T cells with naïve phenotype declines with age.

See this image and copyright information in PMC

Comment on

Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, Mul E, Otto SA, Ruiter AF, Ackermans MT, Miedema F, Borghans JA, de Boer RJ, Tesselaar K. den Braber I, et al. Immunity. 2012 Feb 24;36(2):288-97. doi: 10.1016/j.immuni.2012.02.006. Immunity. 2012. PMID: 22365666

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References

1. den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, et al. Maintenance of peripheral naive T cells: a mouse-main divide. Immunity. 2012 - PubMed
1. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690–695. - PubMed
1. Dutilh BE, de Boer RJ. Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. J Theor Biol. 2003;224:351–358. - PubMed
1. Haluszczak C, Akue AD, Hamilton SE, Johnson LD, Pujanauski L, Teodorovic L, Jameson SC, Kedl RM. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med. 2009;206:435–448. - PMC - PubMed
1. Kilpatrick RD, Rickabaugh T, Hultin LE, Hultin P, Hausner MA, Detels R, Phair J, Jamieson BD. Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol. 2008;180:1499–1507. - PMC - PubMed

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[1] den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, et al. Maintenance of peripheral naive T cells: a mouse-main divide. Immunity. 2012 - PubMed

[2] den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, et al. Maintenance of peripheral naive T cells: a mouse-main divide. Immunity. 2012 - PubMed

[3] Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690–695. - PubMed

[4] Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690–695. - PubMed

[5] Dutilh BE, de Boer RJ. Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. J Theor Biol. 2003;224:351–358. - PubMed

[6] Dutilh BE, de Boer RJ. Decline in excision circles requires homeostatic renewal or homeostatic death of naive T cells. J Theor Biol. 2003;224:351–358. - PubMed

[7] Haluszczak C, Akue AD, Hamilton SE, Johnson LD, Pujanauski L, Teodorovic L, Jameson SC, Kedl RM. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med. 2009;206:435–448. - PMC - PubMed

[8] Haluszczak C, Akue AD, Hamilton SE, Johnson LD, Pujanauski L, Teodorovic L, Jameson SC, Kedl RM. The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med. 2009;206:435–448. - PMC - PubMed

[9] Kilpatrick RD, Rickabaugh T, Hultin LE, Hultin P, Hausner MA, Detels R, Phair J, Jamieson BD. Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol. 2008;180:1499–1507. - PMC - PubMed

[10] Kilpatrick RD, Rickabaugh T, Hultin LE, Hultin P, Hausner MA, Detels R, Phair J, Jamieson BD. Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol. 2008;180:1499–1507. - PMC - PubMed

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Losing TREC with age

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Losing TREC with age

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