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. 2012 Jan 31;125(4):620-37.
doi: 10.1161/CIRCULATIONAHA.111.023838.

Epidemiology and genetics of sudden cardiac death

Rajat Deo  1 , Christine M Albert
Affiliations

Epidemiology and genetics of sudden cardiac death

Rajat Deo et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
Incidence of sudden cardiac arrest according to age, sex, and race in the Chicago CPR project. The study population was comprised of 6,451 patients including 3,207 whites and 2,910 blacks.
Figure 2
Figure 2
Structural Heart Disease in Cardiac Arrest Survivors. These pie charts depict the proportions of underlying cardiac disease among men and women who survive out-of-hospital cardiac arrests. The mean age was 58±12 years for men and 55±17 years for women. Coronary artery disease comprised the principal diagnosis in the majority of men. In contrast, women had more nonischemic heart disease compared to men including dilated cardiomyopathy (19%) and valvular heart disease (13%). CAD indicates coronary artery disease; DCM, dilated cardiomyopathy; VHD, valvular heart disease; SPASM, coronary vasospasm; and RV, right ventricular.
Figure 3
Figure 3
Relative risk of cardiac arrest in blacks compared to whites by age group. The bars represent 95% confidence intervals.
Figure 4
Figure 4
Critical Pathways Leading to Electrical Instability and Sudden Cardiac Death. HTN indicates hypertension; CHD, coronary heart disease; CHF, congestive heart failure; LV, left ventricular; PUFA, polyunsaturated fatty acids; NEFA, non-esterified fatty acids; and SCD, sudden cardiac death.
Figure 5
Figure 5
Underlying arrhythmias of sudden cardiac arrest. VT indicates ventricular tachycardia; and VF, ventricular fibrillation.
Figure 6
Figure 6
Sports engaged in at the time of the SCD events. There were a total of 820 SCD events evaluated in this study. N refers to the absolute number of SCD events that occurred during the specified sport. The percentage refers to the percent of deaths engaged in the specific activity. The pink shaded region represents the number of women. SDs indicate sudden deaths.
Figure 7
Figure 7
Overview of genetic studies. Genome-wide association studies aim to identify common allelic variants that have a low relative risk of disease. Evolution will select for variants that carry a high relative risk of disease; as a result, they will be rare.
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