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. 2011 Feb;7(1):81-6.
doi: 10.5114/aoms.2011.20608. Epub 2011 Mar 8.

Is there a relationship between admission blood glucose level following acute poisoning and clinical outcome?

Ali Mohammad Sabzghabaee  1 , Nastaran Eizadi-Mood, Farzad Gheshlaghi, Nooshin Adib, Leila Safaeian
Affiliations

Is there a relationship between admission blood glucose level following acute poisoning and clinical outcome?

Ali Mohammad Sabzghabaee et al. Arch Med Sci. 2011 Feb.

Abstract

Introduction: The aim of this study was to investigate the relationship between the admission blood glucose level following acute poisoning, severity of acute poisoning and clinical outcome.

Material and methods: This prospective study was conducted on 345 deliberate self-poisoning patients. Standard demographic and clinical information; admission blood glucose level; poisoning severity score and outcome were recorded. Patients with a history of diabetes mellitus, receipt of pre-sampling intravenous dextrose solution or glucocorticoids, and poisoning with toxic agents which produce hyper- or hypoglycaemia were excluded.

Results: Mean age of the patients was 27.5 ±8.6 years. Females outnumbered males (57.9%). Oral ingestion of more than one drug (46.7%) and opiates (14.2%) were the main causes of poisoning. Blood glucose values ranged from 50 mg/dl to 396 mg/dl. Hyper- and hypoglycaemia were observed in 23.8% and 13.91% respectively. A total of 24.41% and 22.92% of the patients in hyper- and hypoglycaemic groups had grade 3 and 4 severity score in comparison with 4.18% in the normoglycaemic group. Development of complications and death were 14.64% and 10.42% in patients with hyper- and hypoglycaemia versus 3.73% in patients with normoglycaemia. A significant difference between normoglycaemic and hyperglycaemic patients in the severity of poisoning and clinical outcome was observed (P < 0.001).

Conclusions: Admission blood glucose levels may have a relationship with the severity of poisoning and clinical outcome following acute poisoning.

Keywords: acute poisoning; blood glucose; hyperglycaemia; outcome; poisoning severity score.

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Figures

Figure 1
Figure 1
Correlation between admission blood glucose levels with poisoning severity scores Poisoning severity score was graded as (0) none, (1) minor, (2) moderate, (3) severe, and (4) fatal. P values are from Kruskal-Wallis non-parametric tests. Thick lines represent the median grade of each group, boxes show the interquartile range and bars represent the maximum and minimum sample values. * p < 0.001 comparing hyperglycaemic patients (> 126) versus normoglycaemic patients (70-126 mg/dl)
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